Dhawale, Kiran D.; Ingale, Ajit P.; Shinde, Sandeep V.; Thorat, Nitin M.; Patil, Limbraj R. published their research in Synthetic Communications in 2021. The article was titled 《ZnO-NPs catalyzed condensation of 2-aminothiophenol and aryl/alkyl nitriles: Efficient green synthesis of 2-substituted benzothiazoles》.HPLC of Formula: 1194-02-1 The article contains the following contents:
The synthesis of 2-substituted benzothiazoles I (R1 = H, 5-Cl; R2 = H, 4-OMe, 2-Br, etc.) has been described using ZnO-nanoparticles as a catalyst. The condensation of 2-aminothiophenol and aryl/alkyl nitriles resulted in the formation of various 2-substituted benzothiazoles under solvent-free reaction conditions. The library of 2-substituted benzothiazoles has been synthesized in good to excellent yield. The reaction has shown a wide range of functional group compatibility for both varyingly substituted 2-aminothiophenols and nitriles. The protocol has many advantages such as faster reaction rate, mild reaction conditions, various functional group compatibility, excellent yield, solvent-free reaction conditions, easy recovery of materials, and excellent catalyst recyclability, among others. The various advantages of this protocol make it a more feasible, economical, and environmentally benign process. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1HPLC of Formula: 1194-02-1)
4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.HPLC of Formula: 1194-02-1
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts