In 2019,Catalysis Communications included an article by Ren, Shishuai; Wang, Yangyang; Yang, Fei; Sun, Hongjian; Li, Xiaoyan. Synthetic Route of C7H4FN. The article was titled 《Dehydration of primary amides to nitriles catalyzed by [CNC]-pincer hydrido cobalt(III) complexes》. The information in the text is summarized as follows:
The dehydration reactions from primary amides to nitriles were catalyzed by the [CNC]-pincer hydrido cobalt(III) complexes [(ortho-F4C6-CH=N-C10H6)Co(III)(H)(PMe3)2], [(2,5-F2C6H2-CH=N-C10H6)Co(III)(H)(PMe3)2] (I) and [(2,4,5-F3C6H-CH=N-C10H6)Co(III)(H)(PMe3)2] as catalysts with (EtO)3SiH as an efficient reducing agent. These hydrido cobalt(III) complexes as catalysts are suitable for many substrates and have good functional group tolerance. Among the three cobalt hydrides, complex I is the best catalyst. This is the first hydrido cobalt complex-catalyzed dehydration of primary amides to nitriles. After reading the article, we found that the author used 4-Fluorobenzonitrile(cas: 1194-02-1Synthetic Route of C7H4FN)
4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Synthetic Route of C7H4FN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts