Product Details of 53005-44-0On September 21, 2012 ,《Pd(OAc)2-Catalyzed Alkoxylation of Arylnitriles via sp2 C-H Bond Activation Using Cyano as the Directing Group》 was published in Journal of Organic Chemistry. The article was written by Li, Wu; Sun, Peipei. The article contains the following contents:
A Pd(OAc)2-catalyzed ortho-alkoxylation of arylnitrile was described. Using cyano as a directing group, the aromatic C-H bond can be functionalized efficiently to generate ortho-alkoxylated arylnitrile derivatives with moderate yields. The optimal reaction conditions were identified after examining various factors such as oxidant, solvent, and reaction temperature The method was compatible to the arylnitriles with either electron-withdrawing or electron-donating groups. The experimental process involved the reaction of 2-Methoxy-6-methylbenzonitrile(cas: 53005-44-0Product Details of 53005-44-0)
2-Methoxy-6-methylbenzonitrile(cas: 53005-44-0) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Product Details of 53005-44-0 Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts