In 2015,Krishna, Patoju M.; Ramachary, Dhevalapally B.; Peesapati, Sruthi published 《Azide-acetonitrile “”click”” reaction triggered by Cs2CO3: the atom-economic, high-yielding synthesis of 5-amino-1,2,3-triazoles》.RSC Advances published the findings.Reference of 2-(3-Bromophenyl)acetonitrile The information in the text is summarized as follows:
Medicinally important 5-amino-1,2,3-triazoles e.g., I, were synthesized via Cs2CO3-catalyzed azide-acetonitrile [3 + 2]-cycloaddn reactions. Aryl azides and arylacetonitriles were employed in this transformation resulting in excellent yields with high regioselectivity. After reading the article, we found that the author used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Reference of 2-(3-Bromophenyl)acetonitrile)
According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Reference of 2-(3-Bromophenyl)acetonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts