Wang, Chang-Sheng; Yu, Yongqi; Sunada, Yusuke; Wang, Chen; Yoshikai, Naohiko published an article in 2022. The article was titled 《Cobalt-Catalyzed Carbo- and Hydrocyanation of Alkynes via C-CN Bond Activation》, and you may find the article in ACS Catalysis.Related Products of 1194-02-1 The information in the text is summarized as follows:
Cobalt-catalyzed carbo- and hydrocyanation reactions of alkynes via C-CN bond cleavage of organic cyanides are reported. A low-valent cobalt-diphosphine catalyst generated by reduction with Zn promotes the arylcyanation of alkynes with trans-selectivity. By contrast, the addition of Zn(OTf)2 to this catalytic system not only accelerates the transformation but also switches the stereoselectivity, affording cis-arylcyanation products. The present catalytic systems prove to be effective for alkenylcyanation using alkenyl cyanides as well as for transfer hydrocyanation using propionitrile as the HCN surrogate. Exptl. and computational studies on arylcyanation have been performed to gain insight into the reaction pathways, including the possible origin of the stereodivergence under cobalt and cobalt/zinc catalysis. In the experimental materials used by the author, we found 4-Fluorobenzonitrile(cas: 1194-02-1Related Products of 1194-02-1)
4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Related Products of 1194-02-1
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts