Kenari, Marziyeh E.; Putman, Joshua I.; Singh, Ravi P.; Fulton, Brandon B.; Phan, Huy; Haimour, Reem K.; Tse, Key; Berthod, Alain; Lovely, Carl J.; Armstrong, Daniel W. published their research in Molecules in 2021. The article was titled 《Enantiomeric separation of new chiral azole compounds》.HPLC of Formula: 1194-02-1 The article contains the following contents:
Twelve new azole compounds (rec/R/S)-I (Ar = Ph, Bn, Bz, allyl, 3,5-bis(trifluoromethyl)phenyl; R = 2,5-dioxo-1-phenylpyrrolidin-3-yl, 2-ethoxy-1-hydroxy-2-oxoethyl), (rec/R/S)-II (R1 = Ph, 4-chlorophenyl, 4-fluorophenyl, 4-methoxyphenyl) and (rec/R/S)-III were synthesized through an ene reaction involving methylidene heterocycles IV and V and N-phenylmaleimide, producing four oxazoles II (R = 2,5-dioxo-1-phenylpyrrolidin-3-yl), five thiazoles I (R = 2,5-dioxo-1-phenylpyrrolidin-3-yl), and one pyridine derivative, III and Et glyoxylate for an oxazole II (R = 2-ethoxy-1-hydroxy-2-oxoethyl) and a thiazole compd I (R = 2-ethoxy-1-hydroxy-2-oxoethyl). The twelve azoles I, II and III have a stereogenic center in their structure. Hence, a method to sep. the enantiomeric pairs, must be provided if any further study of chem. and pharmacol. importance of these compounds is to be accomplished. Six chiral stationary phases were assayed: four were based on macrocyclic glycopeptide selectors and two on linear carbohydrates, i.e., derivatized maltodextrin and amylose. The enantiomers of the entire set of new chiral azole compounds I, II and III were separated using three different mobile phase elution modes: normal phase, polar organic, and reversed phase. The most effective chiral stationary phase was the MaltoShell column, which was able to sep. ten of the twelve compounds I, II and III in one elution mode or another. Structural similarities in the newly synthesized oxazoles II provided some insights into possible chiral recognition mechanisms. The results came from multiple reactions, including the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1HPLC of Formula: 1194-02-1)
4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.HPLC of Formula: 1194-02-1
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts