Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Electric Literature of 31643-49-9.
Karakilic, Emel;Alim, Zuhal;Gunel, Aslihan;Baran, Arif research published ã?A versatile study of novel A3B-type unsymmetric zinc(II) phthalocyanines containing thiazolidin-4-one: Their, carbonic anhydrase I, II isoenzymes, and xanthine oxidase inhibitors evaluationã? the research content is summarized as follows. In this study, four novel phthalocyanine complexes containing zinc metal were synthesized. After preparing the starting compounds 2-(4-hydroxyphenyl)-3-phenylthiazolidin-4-one 1 and 2-(4-(2-hydroxyethoxy)phenyl)-3-phenylthiazolidin-4-one 3 by the conventional method, they were reacted with 4-nitrophthalonitrile sep. using K2CO3 in DMF. Compounds 2 and 4, are well-documented compounds for obtaining phthalocyanines. Subsequently, synthesized phthalonitrile compounds 2 and 4 were reacted with Zn(II) salt at high temperature in the presence of DBU to convert them into targeted sym. (2a, 4a) and unsym. (2b, 4b) phthalocyanines under suitable conditions. Their photochem., photophys., and electrochem. features were then examined These metallophthalocyanines indicated good solubility in some organic solvents, such as DMSO, DMF, THF, DCM, and CHCl3. Furthermore, the structures of ligands (1, 2, 3, 4) were determined by 1H NMR, 13C NMR, and FT-IR spectrometry, while complexes (2a, 2b, 4a, 4b) were determined by FT-IR, UV-Vis, fluorescence, and MALDI-TOF spectrometry. Inhibitory effects of ligand and phthalocyanine compounds (1, 2, 3, 4, 2a, 2b, 4a, 4b) against human erythrocyte carbonic anhydrase I (hCA I) and II (hCA II) isoenzymes, as well as cow’s milk xanthine oxidase (XO), were examined It was found that 2a, 2b, 4a, and 4b had strong inhibition effects at micromolar levels against all three. The compounds 2b and 4b showed stronger inhibition effects for hCA I and II than 2a and 4a. In the case of XO, although the inhibition effects of these mols. (2b, 4a, 4b) were similar, 2a had the strongest inhibition effect. Since CA and XO inhibitors are the target mols. of drug development studies to be used in the treatment of many diseases, the results of this study will aid drug design studies in the development of new XO and CA inhibitors.
Electric Literature of 31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts