Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. COA of Formula: C4H5NO2.
Kerru, Nagaraju;Gummidi, Lalitha;Bhaskaruni, Sandeep V. H. S.;Maddila, Surya Narayana;Jonnalagadda, Sreekantha B. research published ã?One-pot green synthesis of novel 5,10-dihydro-1H-pyrazolo[1,2-b]phthalazine derivatives with eco-friendly biodegradable eggshell powder as efficacious catalystã? the research content is summarized as follows. An eco-friendly and efficient green protocol was developed for the synthesis of pyrazolo[1,2-b]phthalazine derivatives I [Ar = 4-MeSC6H4, 2-MeOC6H4, 3-indolyl, etc.; X = CN, CO(O)Me, CO(O)Et] by using inexpensive biodegradable eggshell powder (ESP) as a heterogeneous catalyst. The four-component one-pot condensation reaction proceeded through Knoevenagel-Michael reaction of active methylene compounds, phthalic anhydride and hydrazine hydrate with substituted aromatic aldehydes in water at 60°C, and gave high yields (93-98%) in 28-45 min. The ESP material was characterized by different anal. techniques (SEM, TEM, XRD, BET, and FT-IR), and was composed of the high percentage of calcium oxides and carbonates, and less percentage of Na and Mg elements (based on EDX anal.). The ESP material displayed recyclability (4 times) without any notable loss of catalytic efficacy. This procedure offered 98% of the atom economy and 100% of carbon efficiency together with significant fiscal and enviro-friendly benefits.
COA of Formula: C4H5NO2, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts