Klintworth, Robin team published research in Beilstein Journal of Organic Chemistry in 2021 | 20099-89-2

COA of Formula: C9H6BrNO, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4�-cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4�-cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. COA of Formula: C9H6BrNO.

Klintworth, Robin;Morgans, Garreth L.;Scalzullo, Stefania M.;de Koning, Charles B.;van Otterlo, Willem A. L.;Michael, Joseph P. research published ã€?Silica gel and microwave-promoted synthesis of dihydropyrrolizines and tetrahydroindolizines from enaminonesã€? the research content is summarized as follows. A wide range of N-(ethoxycarbonylmethyl)enaminones I (R = 4-O2NC6H4, thiophen-2-yl, tert-Bu, etc.), prepared by the Eschenmoser sulfide contraction between N-(ethoxycarbonylmethyl)pyrrolidine-2-thione and various bromomethyl aryl and heteroaryl ketones RC(O)CH2Br, underwent cyclization in the presence of silica gel to give Et 6-(hetero)aryl-2,3-dihydro-1H-pyrrolizine-5-carboxylates II within minutes upon microwave heating in xylene at 150°C. Instead of functioning as a nucleophile, the enaminone acted as an electrophile at its carbonyl group during the cyclization. Yields of the bicyclic products II were generally above 75%. The analogous microwave-assisted reaction to produce Et 2-aryl-5,6,7,8-tetrahydroindolizine-3-carboxylates III [R1 = Ph, 4-MeOC6H4,4-O2NC6H4] from Et 2-[2-(2-oxo-2-arylethylidene)piperidin-1-yl]acetates IV failed in nonpolar solvents, but occurred in ethanol at lower temperature and microwave power, although requiring much longer time. A possible mechanism for the cyclization is presented, and further functionalization of the newly created pyrrole ring in the dihydropyrrolizine core was described.

COA of Formula: C9H6BrNO, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4�-cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4�-cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts