Reference of 4553-07-5, The chemical industry reduces the impact on the environment during synthesis 4553-07-5, name is Ethyl 2-cyano-2-phenylacetate, I believe this compound will play a more active role in future production and life.
General procedure: To a solution of methyleneindolinone (0.1 mmol, 1 equiv), and isocyanide (0.15 mmol, 1.5 equiv) in toluene (0.2 mL) was added catalyst VI (0.005 mmol, 0.05 equiv). The resulting mixture was stirred at room temperature (23C). After the reaction completed, the mixture was quenched with water (5 mL) and extracted with ethyl acetate (2 x 5 mL). The combined organic layer was washed with brine and dried over Na2SO4. The solvent was then removed under reduced pressure. The product was afforded by silica gel flash chromatography using gradient elution (EtOAc/Hexane = 1:10 to 1:6).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-cyano-2-phenylacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Tan, Bin; Zhang, Xuan; Zhong, Guofu; ARKIVOC; vol. 2014; 3; (2014); p. 124 – 142;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts