Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Application In Synthesis of 20099-89-2.
Quintavalla, Arianna;Veronesi, Ruben;Speziali, Laura;Martinelli, Ada;Zaccheroni, Nelsi;Mummolo, Liviana;Lombardo, Marco research published 《 Allenamides Playing Domino: A Redox-Neutral Photocatalytic Synthesis of Functionalized 2-Aminofurans》, the research content is summarized as follows. A photoredox catalytic synthesis of functionalized 2-aminofurans I [R = OPh, 2-oxooxazolidin-3-yl, indol-1-yl, etc.; R1 = Me, Ph, 2-thienyl, etc.; R2 = H, Me, CO2Et, etc.] was proposed starting from α-halo carbonyl substrates and N-allenamides. The use of visible light as green energy source, redox-neutral nature of the transformation allowing to avoid additives and strong oxidants, mild reaction conditions and the functional groups tolerance, low photocatalyst loading and the absence of excess reagents, one-pot formation of three new bonds in a domino sequence, these features of this protocol made it particularly efficient and sustainable. According to mechanistic hypothesis, the transformation was configured as a double radical-polar crossover reaction, in which the photocatalyst was excited, oxidized and reduced twice for each mol. of 2-aminofuran produced. The novelty of the designed synthetic approach also lied in the use of N-allenamides as substrates, which, after the addition of the first electrophilic radical, preserve a further reactive π-system, made possible the addition of a second α-keto radical and enabling the installation of a keto functionality at a remote position. The good yields, broad scope and possibility to further synthetically elaborate the obtained furans made this protocol particularly promising for the construction of useful products.
Application In Synthesis of 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts