Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. HPLC of Formula: 105-34-0.
Ramesh, Perla;Sreenivasulu, Chinnabattigalla;Gorantla, Koteswara Rao;Mallik, Bhabani S.;Satyanarayana, Gedu research published 《 A simple removable aliphatic nitrile template 2-cyano-2,2-di-isobutyl acetic acid for remote meta-selective C-H functionalization》, the research content is summarized as follows. A simple and inexpensive removable aliphatic template was developed for the first time as an effective DG template in promoting remote meta-C-H olefination of arenes. Remarkably, the template was obtained in excellent yields in just two steps and without column chromatog. purification The protocol has an efficient, economical, and practical approach in achieving meta-C-H olefination in good to excellent isolated yields with high levels of meta-selectivity under mild conditions. A wide variety of substituted arenes and olefin coupling partners were well tolerated in this reaction. Moreover, the aliphatic template was found to be advantageous due to its easy synthesis, easy installation/removal, and recyclability.
105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., HPLC of Formula: 105-34-0
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts