In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 939-79-7 as follows. HPLC of Formula: C8H6N2O2
(2) 4-Bromomethyl-3-nitrobenzonitrile A solution of 4-methyl-3-nitrobenzonitrile (30 g), N-bromosuccinimide (37 g) and azobisisobutyronitrile (3.1 g) in carbon tetrachloride (300 ml) was refluxed under heating for 8 hr. To the reaction mixture was added water (100 ml) and the mixture was extracted with chloroform. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the obtained residue was purified by silica gel column chromatography (developing solvent; ethyl acetate_hexane=1:4) and recrystallized from ethyl acetate-hexane to give the title compound (23.7 g) as pale-yellow crystals, m.p.=85-89 C. 1H-NMR(DMSO-d6)delta: 4.96(2H, s), 7.97(1H, d, J=7.9 Hz), 8.22(1H, dd, J=1.3, 7.9 Hz), 8.61(1H, d, J=1.3 Hz); IR(KBr): 3082, 2235, 1614, 1530 cm-1; MS(EI): 241(M+); Elemental analysis: Calculated: C; 39.86, H; 2.09, N; 11.62; Found: C; 40.64, H; 2.15, N; 11.85.
According to the analysis of related databases, 939-79-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Mitsubishi Pharma Corporation; US6455528; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts