Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Electric Literature of 105-34-0.
Tang, Xuejiao;Liu, Kun;Qu, Zeming;Zhan, Junyan;Zhu, Rukui;Teng, Fan;Meng, Lili;Huang, Yanmin;Huang, Chusheng;He, Yimiao;Zhu, Qiang research published 《 Convenient and efficient access to tri- and tetra-substituted 4-fluoropyridines via a [3+2]/[2+1] cyclization reaction》, the research content is summarized as follows. A [3 + 2]/[2 + 1] cycloaddition reaction of gem-difluorocyclopropenes was presented, offering a mild and efficient approach to accessing tri- and tetra-substituted 4-fluoropyridines I [R = Ph, 2-MeC6H4, 6-quinolinyl, etc.; X = COOMe, COOEt, COOBn, etc.] in moderate to good yields with excellent regioselectivity. Multiple synthetic applications, including process-scale reactions, modification of bioactive mols., derivatization reactions and synthesis of the analog of the PKM2 modulator, were subsequently described.
Electric Literature of 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts