On June 22, 2017, Mobashery, Shahriar; Speri, Enrico; Chang, Mayland published a patent.Formula: C12H7N3 The title of the patent was Potentiators of beta-lactam antibiotics and combination therapy. And the patent contained the following:
Proteins of methicillin-resistant Staphylococcus aureus (MRSA), an antibiotic sensor/signal transducer, are phosphorylated on exposure to β-lactam antibiotics. This event is critical for the onset of the biochem. events that unleash induction of antibiotic resistance. The phosphorylation and the antibiotic-resistance phenotype can be abrogated in the presence of phenylpropanenitrile derivatives, eg. I, (X= O, CH2, S, SO2, or a direct bond; R1= CN, SO2Me, CONH2, CO2H, etc.; m= 1,2,3,4; n= 1,2,3,4,5; R2= H, halo, alkyl, alkoxy, heteroaryl, etc.; R3= halo, alkyl, alkoxy, heteroaryl, etc.), that restore susceptibility of the organism to β- lactam antibiotics. The invention thus provides compounds and methods for abrogating antibiotic resistance to β-lactam antibiotics and for treating infections causes by antibiotics prone to developing resistance by potentiating β-lactam antibiotics. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Formula: C12H7N3
The Article related to phenylpropanenitrile derivative betalactam antibiotic resistance mrsa, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Formula: C12H7N3
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts