Srour, Aladdin M.; Dawood, Dina H.; Saleh, Dalia O. published an article in 2021, the title of the article was Synthesis, 3D-pharmacophore modelling and 2D-QSAR study of new pyridine-3-carbonitriles as vasorelaxant active agents.Related Products of 75629-62-8 And the article contains the following content:
A new set of pyridine-3-carbonitriles conjugated with various five-membered ring systems at pyridinyl C-6 were designed and synthesized as vasorelaxant active agents. The majority of the new target derivatives exhibited noteworthy vasodilation efficacy and nine compounds were the most potent analogs with IC50 values = 220.7, 256.7, 164.1, 252.2, 229.8, 265.2, 247.9, 239.1 and 159.8μM, resp., which were superior to that of prazosin hydrochloride (IC50 = 272.8μM). Moreover, four compounds displayed significant α1-adrenergic receptor (α1-AR) blocking efficiency ranging from 65.38 to 87.86% compared with 89.34% for prazosin hydrochloride. Furthermore, a 2D-QSAR study and 3D-pharmacophore model were introduced to carry out compare-fit study for the designed mols. with the generated hypothesis and creating a statistically significant model. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Related Products of 75629-62-8
The Article related to pyridine carbonitrile preparation pharmacophore modeling vasorelaxant active agent hypertension, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Related Products of 75629-62-8
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts