Taylor, Edward C.; Berrier, John V.; Cocuzza, Anthony J.; Kobylecki, Ryszard; McCormack, John J. published an article in 1977, the title of the article was Pteridines. 41. Synthesis and dihydrofolate reductase inhibitory activity of some cycloalka[g]pteridines.COA of Formula: C10H11N3O3S And the article contains the following content:
Eleven homologous 2,4-diaminocycloalka[g]pteridines and derivatives with cycloalkane ring size varying from 5 to 15 were prepared by cyclic condensation of aminomalonitrile tosylate [5098-14-6] with α-oximinocycloalkanones to give aminocyanocycloalka[b]pyrazine oxides followed by deoxygenation and guanidine cyclization, or guanidine cyclization of the pyrazine oxides followed by deoxygenation, or by condensation of 2,4,5,6-tetraaminopyrimidine-HCl [39944-62-2] with a cycloalka-1,2-dione. Inhibition of dihydrofolate reductase [9002-03-3] from Lactobacillus casei, rat liver, L1210, and Trypanosoma cruzi depended on cycloalkane ring size, with 2,4-diaminocyclododeca[g]pteridine (I) [53274-34-3] being most active. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).COA of Formula: C10H11N3O3S
The Article related to dihydrofolate reductase inhibitor aminocycloalkapteridine, cycloalkapteridine dihydrofolate reductase inhibitor, Pharmacodynamics: Structure-Activity and other aspects.COA of Formula: C10H11N3O3S
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts