Ushijima, Sousuke published the artcileOne-pot conversion of aromatic bromides and aromatics into aromatic nitriles, Synthetic Route of 5653-62-3, the main research area is aryl bromide cyanation sequential lithiation DMF addition; arene cyanation sequential lithiation DMF addition; aromatic nitrile green preparation.
Various aromatic bromides and iodides were smoothly converted into the corresponding aromatic nitriles in good to moderate yields by sequential treatment with BuLi and DMF, followed by treatment with I2 in aqueous NH3. The same treatment of typical aromatics and heteroaromatics also provided the corresponding aromatic nitriles in good yields. The present reactions are novel 1-pot methods for the preparation of aromatic nitriles from aromatic bromides and aromatics, resp., through the formation of aryllithiums and their DMF adducts.
Synlett published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Synthetic Route of 5653-62-3.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts