Related Products of 39581-21-0, The chemical industry reduces the impact on the environment during synthesis 39581-21-0, name is N-Butyl-2-cyano-acetamide, I believe this compound will play a more active role in future production and life.
General procedure: To a stirred solution of the cyanoacetamide (2.0mmol) in EtOH (3mL), the ketone or aldehyde (2.0mmol) was added and dissolved. Then, triethylamine (Et3N) (2.0mmol) and S8 (0.25mmol) were added and the reaction mixture was refluxed overnight. Afterwards, it was diluted with EtOAc (25mL) and washed with water (2¡Á25mL) and brine (2¡Á25mL). The combined organic layers were dried over MgSO4, filtrated and the solvent was removed under reduced pressure. Further purification by flash chromatography, with heptane:EtOAc 3:1 (v/v) as eluent, was performed when needed.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Butyl-2-cyano-acetamide, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Eleftheriadis, Nikolaos; Poelman, Hessel; Leus, Niek G.J.; Honrath, Birgit; Neochoritis, Constantinos G.; Dolga, Amalia; Doemling, Alexander; Dekker, Frank J.; European Journal of Medicinal Chemistry; vol. 122; (2016); p. 786 – 801;,
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