Zhang, Guofu published the artcileA cascade process for directly converting nitriles (RCN) to cyanamides (RNHCN) via SO2F2-activated Tiemann rearrangement, Related Products of nitriles-buliding-blocks, the main research area is cyanamide preparation atom economy; amidoxime key intermediate preparation Tiemann rearrangement sulfonyl difluoride promoted; nitrile hydroxylamine oximation.
A simple, mild and practical process for the direct conversion of nitriles RCN (R = H, t-Bu, 2-thienyl, 4-ClC6H4, etc.) to cyanamides RNHCN was newly discovered and exhibited a wide substrate scope as well as great functional group-tolerability (36 examples). In this efficient strategy, in situ generated amidoximes R(NH2)C:NOH obtained from the reaction of nitriles with hydroxylamine subsequently underwent Tiemann rearrangement, producing corresponding cyanamides with great isolated yields under SO2F2. Addnl., the control experiments reportedly shed light on tentative mechanism involved in formation and elimination of key intermediate: a sulfonyl ester.
Organic & Biomolecular Chemistry published new progress about Atom economy. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts