Smith, Cameron J. published the artcile2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety, Quality Control of 34133-58-9, the main research area is CETP inhibitor arylbenzoxazole preparation structure activity.
A series of 2-arylbenzoxazole inhibitors of the cholesterol ester transfer protein (CETP) is described. Structure-activity studies focused on variation of the substitution of the benzoxazole moiety. Substitution at the 5- and 7-positions of the benzoxazole moiety was beneficial for CETP inhibition. Compound 47 was the most potent inhibitor in this series and inhibited CETP with an IC50 of 28 nM.
Bioorganic & Medicinal Chemistry Letters published new progress about Structure-activity relationship. 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, Quality Control of 34133-58-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts