Lesuisse, Dominique published the artcileDevelopment of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson’s disease, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is Parkinson’s disease NURR1 NOT agonist hits HTS SAR neuroprotective.
In the course of a program aimed at identifying Nurr1/NOT agonists for potential treatment of Parkinson’s disease, a few hits from high throughput screening were identified and characterized. A combined optimization pointed to a very narrow and stringent structure activity relationship. A comprehensive program of optimization led to a potent and safe candidate drug displaying neuroprotective and anti-inflammatory activity in several in vitro and in vivo models.
Bioorganic & Medicinal Chemistry Letters published new progress about Anti-inflammatory agents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts