Zhang, Cuicui published the artcileBaicalein triazole prevents respiratory tract infection by RSV through suppression of oxidative damage, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is Secutellaria baicalein triazole respiratory syncytial virus infection antiviral; Anti-inflammatory; Bronchiolitis; Pneumonia; Tumor necrosis.
Baicalein, an isolate of secutellaria baicalensis is known for its anti-inflammatory activity. In the present study, 12-triazole derivatives of baicalein I (R = 2-OH, 4-Me, 2-Br, etc.) were synthesized and evaluated against RSV infected BEAS-2B cells in vitro and in mice model in vivo. The preventive effect of most active compound I (R = 2-CF3) against RSV infection was studied in detail. The compound I (R = 2-CF3) treatment increased IFN-β1 expression in BEAS-2B cells infected with RSV. In BEAS-2B cells treatment with compound I (R = 2-CF3) inhibited RSV-induced secretion of interleukin-6 and -8 cytokines. It decreased RSV-induced nitric oxide & malondialdehyde production and inhibited the RSV-mediated activation of NF-κB, COX-2, Stat3 and MAPK. RT-qPCR showed that compound I (R = 2-CF3) treatment of the RSV-infected mice significantly (P < 0.05) decreased viral load through reduction in the viral replication. In the mice model of RSV-infection compound I (R = 2-CF3) treatment decreased interleukin-6, -8 and tumor necrosis factor-a expression. In summary, compound I (R = 2-CF3) inhibits RSV-infection and prevents pulmonary airway inflammation through the activation of IFN signalling pathway. Microbial Pathogenesis published new progress about Human cell line BEAS-2B. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).
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