Jiao, Jing published the artcileIodine-Promoted Formal [5+1] Annulation of 2-Vinylanilines and Thiurams: A Facile Approach to the Synthesis of 2-Aminoquinolines, Application In Synthesis of 1885-29-6, the main research area is aryl dialkylamino quinoline preparation; vinylaniline tetraalkylthiuram disulfide iodine additive cycloaddition copper triflate catalyst.
A [5+1]-cyclization of 2-vinylanilines RC6H4C(=CH2)(2-NH2C6H3R1) [R = H, 2-Me, 3-Cl, 4-F, etc.; R1 = H, 5-Cl, 4-Me, 3-Et, etc.], 2-(1-naphthalen-1-yl-vinyl)-phenylamine, 2-(1-naphthalen-2-yl-vinyl)-phenylamine with tetraalkylthiuram disulfides (R2)2NC(S)SSC(S)N(R2)2 [R2 = Me, Et, n-Bu] in the presence of iodine and copper(II) triflate was described. This reaction directly employs readily available and low-cost thiuram as both a C1 synthon and a nitrogen source, providing a facile approach to one-step syntheses of a variety of 2-aminoquinolines I [R3 = H, 6-Cl, 7-Me, 8-Et, etc.], N,N-dimethyl-4-(naphthalen-1-yl)quinolin-2-amine, N,N-dimethyl-4-(naphthalen-2-yl)quinolin-2-amine in good to excellent yields.
Synlett published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (vinyl). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts