Sai Kumar, Gobbilla published the artcileHydroboration of nitriles, esters, and amides catalyzed by simple neosilyllithium, Name: Picolinonitrile, the main research area is hydroboration nitrile ester amide preparation aralkyl amine alc; lithium organometallic catalyst hydroboration reduction nitrile ester amide; crystal mol optimized structure picolyl diborylamine.
We present here an efficient method for the hydroboration of organic nitriles, carboxylic esters, and carboxamides with pinacolborane (HBpin) using an alkali metal catalyst, neosilyllithium (LiCH2SiMe3), in neat reaction conditions. The reactions were accomplished with efficient catalytic reactivity and demonstrated by neosilyllithium at room temperature, in solvent-free condition, to afford a high yield of the corresponding N-boryl amines, boryl ethers, and amine hydrochlorides. The protocol for the catalytic reaction presented in this paper is simple and efficient, with diverse substrate scope for nitriles, carboxylic esters, and carboxamides showing excellent functional group tolerance. DLPNO-CCSD(T) calculations were also performed, showing that the hydroboration of nitriles catalyzed by neosilyllithium occurs through the pre-coordination of the nitrile at Lewis acid lithium followed by hydride migration from the B-H entity.
Polyhedron published new progress about Alkali metal compounds Role: CAT (Catalyst Use), USES (Uses) (organometallic). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts