Yamamuro, Daisuke published the artcileSynthesis and biological activity of 5-(4-methoxyphenyl)oxazole derivatives, Safety of 4-(5-Oxazolyl)benzonitrile, the main research area is oxazole thiazole imidazole preparation antibacterial antifungal anticancer agent; 5-(4â?Methoxyphenyl)-oxazole; Caenorhabditis elegans; Hatch inhibition.
5-(4-Methoxyphenyl)oxazole (MPO), originally reported as a synthetic compound, was isolated from a fungal culture broth as an inhibitor of hatch and growth of Caenorhabditis elegans. Nineteen MPO derivatives were chem. synthesized, but showed no effect on C. elegans hatch and growth. These findings strongly suggested that the whole structure of MPO is essential for anti-C. elegans activity. The title compounds thus formed included 5-(4-methoxyphenyl)oxazole, 4-(5-oxazolyl)phenol, 4-(5-oxazolyl)benzoic acid Me ester, 4-[5-(4-methoxyphenyl)-2-oxazolyl]benzoic acid, 5-(4-methoxyphenyl)thiazole, 5-(4-methoxyphenyl)-1H-imidazole. The synthesis of the target compounds was achieved by a reaction of aldehydes with 1-[(isocyanatomethyl)sulfonyl]-4-methylbenzene (TosMIC).
Bioorganic & Medicinal Chemistry Letters published new progress about Acute promyelocytic leukemia (human promyelocytic leukemia cell line). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Safety of 4-(5-Oxazolyl)benzonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts