Hu, Pengfei published the artcileQuaternary-centre-guided synthesis of complex polycyclic terpenes, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is terpene polycyclic synthesis quaternary center guided; conidiogenone synthesis quaternary center guided.
The presence of a quaternary center-a carbon with four other carbons bonded to it-in any given mol. can have a substantial chem. and biol. impact. In many cases, it can enable otherwise challenging chem. For example, quaternary centers induce large rate enhancements in cyclization reactions-known as the Thorpe-Ingold effect-which has application in drug delivery for mols. with modest bioavailability. Similarly, the addition of quaternary centers to a drug candidate can enhance both its activity and its metabolic stability. When present in chiral ligands, catalysts and auxiliaries, quaternary centers can guide reactions toward both improved and unique regio-, stereo- and/or enantioselectivity. However, owing to their distinct steric congestion and conformational restriction, the formation of quaternary centers can be achieved reliably by only a few chem. transformations. For particularly challenging cases-for example, the vicinal all-carbon8, oxa- and aza-quaternary centers9 in mols. such as azadirachtin, scopadulcic acid A and acutumine-the development of target-specific approaches as well as multiple functional-group and redox manipulations is often necessary. It is therefore desirable to establish alternative ways in which quaternary centers can pos. affect and guide synthetic planning. Here we show that if a synthesis is designed such that each quaternary center is deliberately leveraged to simplify the construction of the next-either through rate acceleration or blocking effects-then highly efficient, scalable and modular syntheses can result. This approach is illustrated using the conidiogenone family of terpenes as a representative case; however, this framework provides a distinct planning logic that is applicable to other targets of similar synthetic complexity that contain multiple quaternary centers.
Nature (London, United Kingdom) published new progress about Cyclic terpenes Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts