Chintawar, Chetan C. published the artcileEnantioselective Au(I)/Au(III) Redox Catalysis Enabled by Chiral (P,N)-Ligands, Computed Properties of 1885-29-6, the main research area is oxychroman preparation enantioselective DFT; iodoaryl alkene alc oxyarylation gold catalyst; aminochroman preparation enantioselective DFT; aromatic amine iodoaryl alkene aminoarylation gold catalyst.
The enantioselective Au(I)/Au(III) redox catalysis, enabled by a newly designed hemilabile chiral (P,N)-ligand (ChetPhos) e.g., I was reported. The potential of this concept has been demonstrated by the development of enantioselective 1,2-oxyarylation and 1,2-aminoarylation of alkenes 2-I-3-R1-4-R2-5-R3-6-R4C6OCH2CH=CH2 (R1 = H; R2 = H, F, Me, NO2, etc.; R1R2 = -CH=CHCH=CH-; R3 = H, OMe, C(O)OMe, CF3; R4 = H, Me, OMe) which provided direct access to the medicinally relevant 3-oxy- and 3-aminochromans II [R5 = H, Me, Et, i-Pr, (2-bromophenyl)methyl] III (R6 = 4-nitrophenyl, 4-bromo-2-nitrophenyl, 3-cyanothiophen-2-yl, etc.) (up to 88% yield and 99% ee). DFT studies were carried out to unravel the enantiodetermining step, which revealed that the stronger trans influence of phosphorus allows selective positioning of the substrate in the C2-sym. chiral environment present around nitrogen, imparting a high level of enantioselectivity.
Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (iodoaryl). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts