Miao, Changqing published the artcileIodine-catalyzed coupling of β-hydroxyketones with aromatic amines to form β-aminoketones and Benzo[h]quinolones, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is aminoketone preparation; benzoquinolone preparation; ketone hydroxy aryl amine coupling iodine catalyst.
An iodine-catalyzed coupling of β-hydroxyketones RC(O)(CH2)2OH (R = Me, Ph) with aromatic amines R1NHR2 (R1 = 3-fluorophenyl, biphenyl-4-yl, quinolin-8-yl, etc.; R2 = H, Me) to yield β-aminoketones RC(O)(CH2)2NR1R2 and benzo[h]quinolones I (X = H, Br) have been developed. Noble metallic catalysts, oxidants, α,β-unsaturated ketone intermediates and aza-Michael addition were not involved in this coupling reaction which made it unique when compared to other reactions reported in literature. Inexpensive iodine catalyst, easy accessible raw materials, mild reaction conditions, good functional group tolerance and excellent selectivity made this coupling reaction be a practical method. This reaction can also be scaled up.
Tetrahedron published new progress about Amines, keto Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts