Morozov, Vyacheslav published the artcileMetal-Free Rapid Diastereoselective Construction of Isocryptolepine Core via Electrophilic Dearomatization – Intramolecular Michael Addition Sequence, HPLC of Formula: 1885-29-6, the main research area is methoxyphenyl cyclohexanol aryl nitrile diastereoselective elecrophilic dearomatization Michael addition; indoloacridinone preparation; xanthenoindolone preparation.
A method for rapid construction of indolo[3,2-l]acridin-7-one systems bearing isocryptolepine scaffold was described. Metal-free condensation of (4-methoxyphenyl)cyclohexan carbinols with ortho-amino/hydroxybenzonitriles in concentrated sulfuric acid yielded polyannulated compounds with four new stereogenic centers in a highly diastereoselective manner. The reaction included elecrophilic dearomatization of methoxyarene, formation of spirocyclic intermediate and intramol. 1,4-nucleophilic addition sequence.
ChemistrySelect published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts