Jatangi, Nagesh published the artcileBase-catalyzed synthesis of quinazolines in aqueous medium, Application In Synthesis of 1885-29-6, the main research area is quinazoline preparation green chem; ketimine preparation aryl isothiocyanate heterocyclization sodium hydroxide catalyst; aminobenzonitrile magnesium bromide Grignard reaction.
An alternative green and step economy reaction of readily available 2-aminobenzonitriles 2-NH2-5-XC6H3CN (X = H, Cl, OCH3, NO2, etc.) with various organometallic reagents RMgBr (R = Ph, 3-methoxyphenyl, Bu, etc.) led to ortho-aminoaryl NAH ketimine 2-NH2-5-XC6H3C(R)=NH species. The subsequent base catalyzed NAC bond formation with various isothiocyanates ArNCS (Ar = Ph, 4-nitrophenyl, 2,4-difluorophenyl, etc.) afforded quinazoline scaffolds I in aqueous medium. The salient features of this protocol are use of readily available inexpensive precursors, water as a green environmentally benign solvent, short reaction time, operational simplicity, easy workup procedure and good functional group tolerance.
Tetrahedron Letters published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts