Bergagnini-Kolev, Mackenzie published the artcileSynthesis of trifluoromethyl substituted nucleophilic glycine equivalents and the investigation of their potential for the preparation of α-amino acids, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is amino acid synthesis trifluoromethyl nucleophilic glycine equivalent; substituted pyroglutamic acid synthesis; nickel complex glycine Schiff base phase transfer catalyzed alkylation; oxazoladinone amide unsaturated substituted carboxylic acid Michael addition.
The synthetic preparation of several Ni(II) complexed Schiff bases of glycine will be introduced, as well as investigations into their reactivity and utility. Key to these investigations is the incorporation of electron-withdrawing trifluoromethyl groups within the framework of the conjugated system that stabilizes the enolate derived from the glycine component. Reactivity was evaluated for each of the complexes under phase transfer catalyzed alkylations with hydroxide bases, as well as the DBU catalyzed Michael additions of optically active 3′-substituted-2-oxazoladinone amides of unsaturated carboxylic acids. It was found that the trifluoromethyl containing nucleophilic glycine equivalent were more reactive than their non-trifluoromethyl analogs in both reaction types. Therefore, the application of these modified Ni(II) complexes of glycine Schiff bases are useful for the preparation of α-amino acids through phase transfer catalyzed alkylation as well as the preparation of optically pure β-substituted pyroglutamic acid precursors.
Tetrahedron published new progress about Amino acids Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts