Wang, Qiang published the artcileBase-Promoted Nitrile-Alkyne Domino-Type Cyclization: A General Method to Trisubstituted Imidazoles, Application In Synthesis of 100-70-9, the main research area is trisubstituted imidazole preparation; alkyne nitrile potassium tert butylate domino cyclization.
An efficient base promoted nitrile-alkyne domino-type cyclization for multicomponent assembly of imidazoles from alkynes, nitriles, and tBuOK has been developed, which could run even in the absence of solvent on a gram scale with complete atom economy. This method contributes directly to reaching the synthesis of valuable imidazole derivatives from readily available raw materials.
Organic Letters published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts