Kalogirou, Andreas S. published the artcileSynthesis of 2-Cyanoquinazolin-4-ones from 3′,5′-Dichloro-1H-spiro(quinazoline-2,4′-[1,2,6]thiadiazin)-4(3H)-ones, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is cyanoquinazolinone preparation; dichloro spiroquinazolinone thiadiazine preparation triphenylphosphine catalyst degradation.
A two-step synthesis of five 2-cyanoquinazolin-4-ones I (R = Me, Ph) and II (R1 = H, Me, Ph) starting from 3,4,4,5-tetrachloro-4H-1,2,6-thiadiazine is presented. The latter reacts with 2-aminobenzamides 2-NHR2(C6H4)C(O)NHR3 (R2 = H, Me, Ph; R3 = H, Me, Ph) to give 3′,5′-dichloro-1H-spiro(quinazoline-2,4′-[1,2,6]thiadiazin)-4(3H)-ones III, which can be degraded with either excess polymer bound triphenylphosphine or catalytic amounts of benzyltriethylammonium iodide to give the 2-cyanoquinazolin-4-ones I and II in 46-97% yields. The single crystal X-ray diffraction anal. of 2-cyanoquinazolin-4(3H)-one was also reported.
ChemistrySelect published new progress about Benzamides Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts