Huang, Ziwei published the artcileThe Synthesis and Application of 2-Cyano and -Ester Containing Anilines: Selective Copper-Catalyzed Reductive Amination, N -Benzylation, and Cyclization Reactions, Computed Properties of 1885-29-6, the main research area is indoloindole preparation green chem; benzyl bromide cyano iodo amine benzylation cyclization copper catalyst; cyano amine preparation regioselective chemoselective green chem fluorescence; aldehyde aminobenzonitrile reductive amination copper catalyst; ester amine preparation regioselective chemoselective fluorescence; aminobenzoate aldehyde reductive amination copper catalyst.
A convenient and practical pathway to 2-cyano and 2-ester anilines 2-R-3-R1-4-R2-5-R3C6HNHCH2R4 (R = CN, C(O)OMe, butoxycarbonyl; R1 = H, Cl; R2 = H, F, OMe; R3 = H, Me, Cl, OMe; R4 = Ph, 2-iodophenyl, furan-2-yl, etc.) is described via efficient and selective copper(II)-catalyzed reductive amination via hydrosilylation process. Both 2-cyano and 2-ester anilines were successfully synthesized with good functional group tolerance and high selectivity. The application of the 2-cyano and -iodine containing anilines 2-CN-4-R2-5-R3C6H2NHCH2-2-IC6H4 was developed in the synthesis of indoloindole derivatives I (Ar = Ph, 2-methylphenyl, 4-fluorophenyl, etc.) via CuSO4-catalyzed N-benzylation and cyclization reaction in ‘one pot’. More interestingly, the photophys. property investigations of these 2-cyano and 2-ester containing anilines exhibit excellent fluorescent properties, which have great potential application in the development of interesting near-UV optical devices in the near future.
Synthesis published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts