Senadi, Gopal Chandru published the artcileSustainable methine sources for the synthesis of heterocycles under metal- and peroxide-free conditions, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is quinazolinone green preparation; alc amino benzamide cascade oxidative cleavage; ether amino benzamide cascade oxidative cleavage; benzimidazole green preparation; amino benzylamine methoxyethanol cascade oxidative cleavage.
Alcs. and ethers were identified as sustainable methine sources for synthesizing quinazolinones I [R = H, 8-Me, 7-NO2, etc.; R1 = OMe, allyl, Ph, etc,] and benzimidazoles II [R2 = H, 5-Cl, 6,7-di-Me, etc.] using a combination of TsOH·H2O/O2 and appropriate bis-nucleophiles for the first time. Deuterium labeling studies clearly proved that the C2 hydrogen of the synthesized heterocycles came from the methine source. These unique reaction conditions were successfully applied to the synthesis of echinozolinone I [R = H; R1 = CH2CH2OH, 2-(1H-indol-3-yl)ethyl] (a common precursor of rutaecarpine and (±) evodiamine) and dimedazole II [R2 = 5,6-di-Me]. Notable features of this method included its low toxicity, use of com. feedstocks as substrates, low cost, broad functional group tolerance and suitability for a wide range of bis-nucleophilic starting materials.
Green Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts