Zhang, Zhi-hao published the artcileSynthesis, In Vitro Antiplatelet Activity of 4-Ethoxy-isophthalamides, HPLC of Formula: 1885-29-6, the main research area is ethoxyisophthalamide preparation antiplatelet activity.
The structural design, preparation, spectral confirmation of thirteen new 4-ethoxyisophthalamide compounds I (R = 2-OEt, 3-Br, 4-I, etc.; n = 0, 1) were described and completes their preliminary screening of in vitro antiplatelet activity in response to the following inducers: ADP (ADP) and collagen. Among them, when ADP was used as an inducer, compounds having activities higher or close to picotamide and IC50 values revealed that one compound I (R = m-CF3, n = 0) (IC50 : 0.26μmol L-1) was more than three times more active than pos. control drug picotamide. Meanwhile, cytotoxic effects in vitro of compound I (R = 4-I, n = 0) and compound I (R = m-CF3, n = 0) on L929 cells were analyzed. The structure-activity relationship showed that when electron-withdrawing groups nitro or trifluoromethyl are introduced at the meta- or para- position of the two side chain benzene rings, it is beneficial on the whole to the improvement of antiplatelet activity.
ChemistrySelect published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts