Penaranda Gomez, Angelica published the artcileI2/DMSO-Promoted Synthesis of Chromeno[4,3- b]quinolines through an Imine Formation/Aza-Diels-Alder/Aromatization Tandem Reaction under Metal-Catalyst- and Photosensitizer-Free Conditions, SDS of cas: 1885-29-6, the main research area is cinnamyl salicylaldehyde aryl amine iodine catalyst tandem reaction; chromenoquinoline preparation green chem.
A tandem approach was developed for the efficient synthesis of substituted chromeno[4,3- b]quinolines from arylamines and O-cinnamyl salicylaldehydes under metal-catalyst- and photosensitizer-free reaction conditions. This method was based on an inexpensive I2/DMSO system in which mol. iodine first acted as a Lewis acid to promote the formation of the corresponding imine bearing the alkene moiety; then, this species fulfilled a second role by catalyzing an intramol. aza-Diels-Alder cycloaddition to generate the resp. tetrahydrochromenoquinoline as an intermediate. Finally, the dual behavior of DMSO as an oxidant and as a solvent proved crucial at this stage, allowing the regeneration of I2 and promoting the aromatization of the tetrahydrochromenoquinoline intermediates to yield the desired 7-aryl-6 H-chromeno[4,3- b]quinolines. This protocol was mild and easy to perform, features high step-economy (tandem process) and provides a new access to biol. important nitrogen- and oxygen-containing heterocyclic mols.
Synthesis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts