Wilders, Alison M. published the artcilePd-Catalyzed Cross-Coupling of Hindered, Electron-Deficient Anilines with Bulky (Hetero)aryl Halides Using Biaryl Phosphorinane Ligands, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is Buchwald Hartwig amination aryl halide palladium phosphine phosphorinane catalyst; phosphorinane oxo preparation phospha Michael addition cyclization dienone; primary phosphine phospha Michael reaction preparation oxophosphorinane amination catalyst; high throughput evaluation Buchwald Hartwig amination aryl halide aniline.
Biaryl phosphorinane ligands derived from addition of biaryl primary phosphines to trans,trans-dibenzylideneacetone (AlisonPhos and AliPhos) form highly active ligands for Pd-catalyzed coupling of hindered, electron-deficient anilines with hindered (hetero)aryl halides, a challenging class of C-N cross-coupling reaction with few precedents. Broad substrate scope and functional group tolerance were observed under the reaction conditions. Computational studies suggest that ligands containing Ph substituents provide greater activity through more favorable aniline binding in the catalytic cycle in comparison to alkyl-substituted phosphorinanes. A general and high-yielding procedure for the synthesis of biaryl phosphorinanes by phospha-Michael addition of primary biarylphosphines to 1,4-dien-3-ones in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP), under relatively mild conditions (23-110°C), is also described. HFIP as the solvent significantly accelerates the phospha-Michael addition, allowing the preparation of previously inaccessible ligands and higher yields overall.
ACS Catalysis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts