Author: Jessica.F

Andersson, Carlaxel published the artcileThe influence of metal coordination on ligand geometry: the structures of 2-(diphenylphosphino)benzyl methyl ether and bis(2-(diphenylphosphino)benzyl methyl ether)palladium(II)triflate, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate, the publication is Journal of Molecular Structure (1999), 479(1), 1-11, database is CAplus.

The structures of 2-(diphenylphosphino)benzyl Me ether (I) and bis(2-(diphenylphosphino)benzyl Me ether)palladium(II)triflate (II) were determined by x-ray crystallog. II is a potential catalyst in organic synthesis and was prepared by treating tetrakis(acetonitrile)palladium bistriflate with 2-(diphenylphosphino)benzyl Me ether in toluene for 16 h at room temperature I crystallizes in monoclinic space group P2₁/a with a 7.873(2), b 14.805(3), c 14.262(5) Å, β 91.34(3)°, and Z = 4. II crystallizes in triclinic space group P1̅ with a 10.2886(6), b 13.951(1), c 15.6339(9) Å, α 89.171(5), β 73.791(5), γ 83.463(6)°, and Z = 2. Both structures were solved by direct methods and the refinements resulted in the R-values 0.066 and 0.052 for I and II, resp. The bidentate ligand binds to Pd(II) in a cis-configuration. The Pd-O distances are 2.153(3) and 2.142(3) A and the Pd-P distances 2.252(1) and 2.256(1) Å. The effects of packing and metal complexation on the geometry of I are discussed and the differences are compared by half-normal probability plot anal.

Journal of Molecular Structure published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Visser, Michael S. published the artcileSynthesis and biological evaluation of novel hygromycin A antibacterial agents, Name: 2-(Chloromethyl)benzonitrile, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(22), 6730-6734, database is CAplus and MEDLINE.

Novel hygromycin A derivatives, e.g. I, bearing a variety of functionalized aminocyclitol moieties have been synthesized in an effort to increase the antibacterial activity and drug-like properties of this class of agents. A systematic study of the effect of alkylation and removal of the hydroxyls of the aminocyclitol directed us to a series of alkylated aminocyclitol derivatives with improved Gram-pos. activity.

Bioorganic & Medicinal Chemistry Letters published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C5H6BNO2, Name: 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Gutierrez-Bonet, Alvaro published the artcileFe-Catalyzed Regiodivergent [1,2]-Shift of α-Aryl Aldehydes, Category: nitriles-buliding-blocks, the publication is Journal of the American Chemical Society (2013), 135(34), 12576-12579, database is CAplus and MEDLINE.

An Fe-catalyzed conversion of aldehydes to ketones via [1,2]-shift has been developed. This skeletal rearrangement shows a wide substrate scope and chemoselectivity profile while exhibiting an excellent [1,2]-aryl or [1,2]-alkyl shift selectivity that is easily switched by electronic effects.

Journal of the American Chemical Society published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Category: nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Xu, Lili published the artcileProcess improvement on synthesis of 1,4-bis(o-cyanostyryl) benzene, Name: 2-(Chloromethyl)benzonitrile, the publication is Yingyong Huagong (2010), 39(3), 456-458, 462, database is CAplus.

1,4-Dimethylbenzene was chlorinated by dry Cl₂, then the mixed chloride products was hydrolyzed to terephthalaldehyde by hexamethylenetetramine. The purity of the product was 99.5% and the yield was 78.4%. Di-Et o-cyanobenzyl phosphonate was synthesized by the esterification reaction of tri-Et phosphatidate and o-cyanobenzyl chloride dissolved in dimethylbenzene, the yield was 86.5%. 1,4-Bis(o-cyanostyryl) -benzene was synthesized from di-Et o-cyanobenzyl phosphonate and terephthalaldehyde. The purity of the product is 99.5% (HPLC) and the yield is 84.1%.

Yingyong Huagong published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C22H38O2, Name: 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Wang, Yanping published the artcileAn efficient cyanosilylation of aldehydes with trimethylsilyl cyanide catalysed by MgI₂ etherate, COA of Formula: C8H6ClNO, the publication is Journal of Chemical Research (2012), 36(10), 566-567, database is CAplus.

A convenient procedure for the synthesis of cyanohydrins by the addition of Me₃SiCN to aromatic aldehydes, heteroaromatic aldehydes, aliphatic aldehydes and unsaturated aldehydes catalyzed by MgI₂.(OEt₂)_n in good to excellent yields was described.

Journal of Chemical Research published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, COA of Formula: C8H6ClNO.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Kang, Dongwei published the artcileSynthesis and preliminary antiviral activities of piperidine-substituted purines against HIV and influenza A/H1N1 infections, Product Details of C8H6ClN, the publication is Chemical Biology & Drug Design (2015), 86(4), 568-577, database is CAplus and MEDLINE.

We have developed a series of N²-(1-(substituted-aryl)piperidin-4-yl)-N⁶-mesityl-9H-purine-2,6-diamine derivatives as potent antiviral agents. Preliminary biol. evaluation indicated that nearly half of them possessed remarkable HIV inhibitory potencies in cellular assays. In particular, FZJ13 appeared to be the most notable one, which displayed anti-HIV-1 activity compared to 3TC. Moreover, an unexpected finding was that FZJ05 displayed significant potency against influenza A/H1N1 (strain A/PR/8/34) in Madin-Darby canine kidney cells with EC₅₀ values much lower than those of ribavirin, amantadine, and rimantadine. The results suggest that these novel purine derivatives have the potential to be further developed as new therapeutic agents against HIV-1 or influenza virus.

Chemical Biology & Drug Design published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Product Details of C8H6ClN.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Jeng, Huey-Jiuan published the artcileFormation of pyrrole derivatives from heteroatom-substituted acetonitriles, Synthetic Route of 5098-14-6, the publication is Journal of the Chinese Chemical Society (Taipei) (1994), 41(6), 803-11, database is CAplus.

Aminomalononitrile reacted with conjugated carbonyl compounds to give 3H-pyrrolines. Treatment of 2-chloro-2-phenylthioacetonitrile with alkenes in the presence of potassium t-butoxide afforded 1-phenylthiocyclopropanecarbonitriles, which reacted with nucleophiles in 1,2-, 1,4- or 1,6-addition modes. The 1,2-adducts (cyclopropylimines) rearranged in situ to give substituted pyrroles.

Journal of the Chinese Chemical Society (Taipei) published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Synthetic Route of 5098-14-6.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Chen, Weiqiang published the artcileThe Cyclohexa-2,5-dienyl Group as a Placeholder for Hydrogen: Organocatalytic Michael Addition of an Acetaldehyde Surrogate, SDS of cas: 5153-73-1, the publication is Chemistry – A European Journal (2020), 26(66), 15126-15129, database is CAplus and MEDLINE.

An aldehyde with a cyclohexa-2,5-dienyl group in the α-position is introduced as a storable surrogate of highly reactive acetaldehyde. The cyclohexa-2,5-dienyl unit is compatible with an enantioselective Michael addition to nitroalkenes promoted by a Hayashi-Jorgensen catalyst and can be removed by a boron Lewis acid mediated C-C bond cleavage. The robust two-step sequence does not require a large excess of the aldehyde component that is typically needed when directly using acetaldehyde.

Chemistry – A European Journal published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, SDS of cas: 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Bizzarri, Bruno Mattia published the artcileAminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity, SDS of cas: 5098-14-6, the publication is RSC Advances (2021), 11(48), 30020-30029, database is CAplus and MEDLINE.

Amino imidazole carbonitrile derivatives decorated with α-amino acid side-chains have been synthesized by a multicomponent microwave assisted reaction inspired by the prebiotic chem. of aminomalononitrile as a tool for generating high chem. diversity. These compounds were used as annulation synthons for the preparation of 8,9-disubstituted-6,9-dihydro-1H-purin-6-ones by reaction with formic acid as a simple C-1 donor reagent. The novel heterocycles were characterized by significant activity against influenza A virus, amino imidazole carbonitrile derivatives showing the highest activity. Thus, the chem. complexity generated by prebiotic chem. furnished a general tool for the identification of novel antiviral agents.

RSC Advances published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, SDS of cas: 5098-14-6.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Bray, Katharine L. published the artcileHalide redistribution in Pd-catalyzed 1,6-diene cycloisomerization, Synthetic Route of 68569-14-2, the publication is Chemical Communications (Cambridge) (2001), 187-188, database is CAplus.

[(MeCN)₃PdCl]⁺, generated in situ, reversibly disproportionates to give [(MeCN)₂PdCl₂] and [(MeCN)₄Pd]²⁺. The neutral species is a reactive and highly regioselective catalyst for 1,6-diene cycloisomerization.

Chemical Communications (Cambridge) published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, Synthetic Route of 68569-14-2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts