Author: Jessica.F

Carpenter, K. published the artcileHerbicidal activity of halogenohydroxybenzonitriles, SDS of cas: 3336-34-3, the publication is Mededelingen van de Landbouwhogeschool en de Opzoekingsstations van de Staat te Gent (1964), 29(3), 644-54, database is CAplus.

The activities of analogs of ioxynil (4-hydroxy-3,5-diiodobenzonitrile) (I) were compared in greenhouse experiments I applied in amounts of 0.25 kg./ha. to the leaves of seedlings, kills weed spp. belonging to the Compositae, Cruciferae, Chenopodiaceae, Polygonaceae, and Caryophyllaceae families. Replacement of one or both of the iodine atoms in I by Cl or Br influences the herbicidal spectrum, but not the general level of herbicidal activity as determined in the greenhouse. However, the number of halogens introduced and their positions in the nucleus are both critical, since the peak of activity occurs with dihalogenation in the 3- and 5-positions. Conversion of the CN group into either a CONH₂ or COOH group and changes in the position of the OH group are all detrimental to activity. Acetylation of the OH group results in no loss of activity, but methylation causes some reduction in the herbicidal activity.

Mededelingen van de Landbouwhogeschool en de Opzoekingsstations van de Staat te Gent published new progress about 3336-34-3. 3336-34-3 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Phenol, name is 2,6-Dichloro-3-hydroxybenzonitrile, and the molecular formula is C7H3Cl2NO, SDS of cas: 3336-34-3.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Khanna, Avinash published the artcileDesign, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time, HPLC of Formula: 57663-05-5, the publication is ACS Medicinal Chemistry Letters (2020), 11(6), 1205-1212, database is CAplus and MEDLINE.

Histone methyltransferase EZH2, which is the catalytic subunit of the PRC2 complex, catalyzes the methylation of histone H3K27-a transcriptionally repressive post-translational modification (PTM). EZH2 is commonly mutated in hematol. malignancies and frequently overexpressed in solid tumors, where its expression level often correlates with poor prognosis. First generation EZH2 inhibitors are beginning to show clin. benefit, and we believe that a second generation EZH2 inhibitor could further build upon this foundation to fully realize the therapeutic potential of EZH2 inhibition. During our medicinal chem. campaign, we identified 4-thiomethyl pyridone as a key modification that led to significantly increased potency and prolonged residence time. Leveraging this finding, we optimized a series of EZH2 inhibitors, with enhanced antitumor activity and improved physiochem. properties, which have the potential to expand the clin. use of EZH2 inhibition.

ACS Medicinal Chemistry Letters published new progress about 57663-05-5. 57663-05-5 belongs to nitriles-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Tetrahydropyrimidins, name is 6-Methyl-4-(methylthio)-2-oxo-1,2-dihydropyridine-3-carbonitrile, and the molecular formula is C8H8N2OS, HPLC of Formula: 57663-05-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Krumova, Katerina published the artcileBodipy Dyes with Tunable Redox Potentials and Functional Groups for Further Tethering: Preparation, Electrochemical, and Spectroscopic Characterization, Name: 2,4-Dimethyl-1H-pyrrole-3-carbonitrile, the publication is Journal of the American Chemical Society (2010), 132(49), 17560-17569, database is CAplus and MEDLINE.

The preparation, spectroscopic, and electrochem. characterization of a family of 16 new bodipy dyes with tunable redox potentials and versatile functional groups is reported. Electron-withdrawing or -donating groups (Et, H, Cl, or CN) at positions C2 and C6 enabled tuning the redox potentials within a ca. 0.7 eV window without significantly affecting either the HOMO-LUMO gap or the absorption and emission spectra. Hydroxymethyl or formyl groups at the meso (C8) position in turn provided a handle for covalent tethering to receptors and biomols. of interest, which dispenses with the more commonly used meso-aryl moiety as a means to tag mols. The dyes can thus be coupled to both electrophiles and nucleophiles. Importantly, it is shown that meso-formyl bodipy dyes are nonemissive and have significantly lower molar extinction coefficients compared to their meso-hydroxymethyl and meso-acetoxymethyl counterparts (which in turn are bright, with emission quantum yields in the range of 0.7-1). The nonemissive meso-formyl bodipy dyes thus provide unique opportunities as fluorogenic probes of nucleophilic attack and as fluorescent labeling agents where uncoupled fluorophores will not contribute to the fluorescence background. Overall, the new bodipy dyes reported here are promising candidates for the preparation of fluorescent sensors relying on photoinduced electron transfer and may find use in a number of fluorescent-labeling protocols.

Journal of the American Chemical Society published new progress about 26187-28-0. 26187-28-0 belongs to nitriles-buliding-blocks, auxiliary class Pyrrole,Nitrile, name is 2,4-Dimethyl-1H-pyrrole-3-carbonitrile, and the molecular formula is C7H8N2, Name: 2,4-Dimethyl-1H-pyrrole-3-carbonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Bartlett, Robert T. published the artcileSynthesis and pharmacological evaluation of a series of analogs of 1-methylisoguanosine, Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate, the publication is Journal of Medicinal Chemistry (1981), 24(8), 947-54, database is CAplus and MEDLINE.

Analogs of 1-methylisoguanosine (I, R = Me, R¹ = H, R² = OH) were evaluated as muscle relaxants, antiinflammatory agents, allergy inhibitors, and for cardiovascular activity. Cyclizing imidazole nucleoside II with RNCO (R = Et, Bu, octyl, Ph) and deprotecting gave I (R = Et, Bu, octyl, Ph; R¹ = H, R² = OH). Bromination of I (R = Me, R¹ = H, R² = OH) with Br₂-H₂O gave I (R = Me, R¹ = Br, R² = OH) which reacted with N₂H₄ to give I (R = Me, R¹ = NHNH₂, R² = OH). This was cleaved with Raney Ni to give I (R = Me, R¹ = NH₂, R² = OH). Deamination of 1-methylguanosine with NaNO₂ in aqueous AcOH gave 1-methylxanthosine. Iodination of I (R = Me, R¹ = H, R² = OH) with Me(PhO)₃P⁺I^– gave I (R = Me, R¹ = H, R² = iodo) which was cyclized to III or deiodinated to I (R = Me, R¹ = R² = H). The phosphate ester I (R = Me, R¹ = H, R² = OPO₃^2-) was prepared as well as cyclic phosphate IV. C-Nucleoside V was prepared from Me β-D-ribofuranosyl-1-carboximidate. Cyclizing the 9-(2-hydroxyethoxy)methyl analog of II with MeNCO gave acyclic analog VI. Similarly prepared was the β-D-arabinofuranosyl analog of I (R = Me, R¹ = H, R² = OH).

Journal of Medicinal Chemistry published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Pearson, David M. published the artcileOxidatively Resistant Ligands for Palladium-Catalyzed Aerobic Alcohol Oxidation, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate, the publication is Organometallics (2011), 30(6), 1445-1453, database is CAplus.

[(Neocuproine)Pd(OAc)]₂[OTf]₂ (1) catalyzes the aerobic oxidation of 2-heptanol at room temperature, but competitive ligand oxidation leads to low catalyst lifetimes. In an effort to mitigate the oxidative degradation of the ligand, a variety of Pd complexes ligated by fluorinated phenanthrolines (bis-2,9-(trifluoromethyl)-1,10-phenanthroline (btfm-phen), 4-methyl-2-(trifluoromethyl)-1,10-phenanthroline (tfmm-phen), and 2-(o-difluorophenyl)-1,10-phenanthroline (odfp-phen)) were prepared and tested. Active catalyst precursors were generated by in situ conproportionation of (N-N)Pd(OAc)₂ and [(N-N)Pd(NCCH₃)₂[OTf]₂]. Pd complexes derived from tfmm-phen catalyzed the aerobic oxidation of 2-heptanol at room temperature with up to 22 turnovers, nearly double that of 1.

Organometallics published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zuck, Donald A. published the artcileStabilization of vitamin B₁₂. II. α-Hydroxy nitriles, Recommanded Product: 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, the publication is Journal of Pharmaceutical Sciences (1963), 63-6, database is CAplus.

α-Hydroxy nitriles and esters of mandelonitrile were effective stabilizers of I except under conditions of prolonged exposure to ultraviolet light when decomposition was more rapid than in the controls.

Journal of Pharmaceutical Sciences published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C10H11NO4, Recommanded Product: 2-(2-Chlorophenyl)-2-hydroxyacetonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Hutchinson, Daniel John published the artcileSupramolecular self-assembly of heterobimetallic complexes: a new N,P-based, selective heteroditopic ligand, SDS of cas: 68569-14-2, the publication is Dalton Transactions (2018), 47(4), 1053-1061, database is CAplus and MEDLINE.

Pyrimidine-hydrazone and phosphole architectures were combined to create a new heteroditopic ligand capable of forming heterobimetallic Zn^II/Pd^II, Pb^II/Pd^II and Cu^II/Pd^II complexes in high yielding stepwise or one pot reactions. The catalytic activity of these complexes in Heck coupling and Miyaura borylation reactions was studied.

Dalton Transactions published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, SDS of cas: 68569-14-2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Liu, Bei-Bei published the artcileAqueous Reaction of Alcohols, Organohalides, and Odorless Sodium Thiosulfate under Transition-Metal-Free Conditions: Synthesis of Unsymmetrical Aryl Sulfides via Dual C-S Bond Formation, Synthetic Route of 612-13-5, the publication is Journal of Organic Chemistry (2017), 82(19), 10174-10180, database is CAplus and MEDLINE.

A transition-metal-free process for the synthesis of unsym. aryl sulfides via dual C-S bond formation by a one-pot three-component reaction of alcs., organohalides, and odorless sodium thiosulfate in water was developed. In addition, the aryl sulfides could also be prepared by the reaction of the corresponding alcs. and Bunte salts under the identical conditions. This protocol provides a green and efficient manner for the construction of various unsym. aryl sulfides.

Journal of Organic Chemistry published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Synthetic Route of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Sathish, Manda published the artcileIron-Mediated One-Pot Synthesis of 3,5-Diarylpyridines from β-Nitrostyrenes, Quality Control of 5153-73-1, the publication is Journal of Organic Chemistry (2016), 81(5), 2159-2165, database is CAplus and MEDLINE.

An operationally simple and mild one-pot protocol for the synthesis of a variety of 3,5-diarylpyridines from β-nitrostyrenes was achieved by using elemental iron. This reaction proceeds via reduction of the nitro group, resulting in in situ imine formation followed by trimol. condensation with concomitant debenzylative aromatization. By employing this method, a series of sym. and unsym. 3,5-diarylpyridines were synthesized with good to excellent yields. In addition, this method was also utilized for the synthesis of Sch-21418 (I), an anti-inflammatory agent on gram scale.

Journal of Organic Chemistry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Quality Control of 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Huang, Zijun published the artcileRegioselectivity inversion tuned by iron(III) salts in palladium-catalyzed carbonylations, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(32), 3967-3970, database is CAplus and MEDLINE.

By using cheap and abundant iron(III) salts, the hydroxycarbonylations of both aromatic and aliphatic alkenes were significantly enhanced in both reactivity and selectivity (iso/n or n/iso up to >99 : 1). Moreover, Pd-catalyzed carbonylation selectivity can be switched from branched to linear by using different Fe(III) salts. In addition, similar results were obtained for the carbonylation of secondary alcs.

Chemical Communications (Cambridge, United Kingdom) published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C10H12F6N4O6PdS2, Recommanded Product: Tetrakis(acetonitrile)palladium(II) Ditriflate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts