Author: Jessica.F

Liu, Liu published the artcileSynthesis and WORM memory performance of polycarbazole derivatives with different electron acceptors in the side chain, COA of Formula: C19H10Br2N2, the publication is Gongneng Gaofenzi Xuebao (2016), 29(2), 163-171, 181, database is CAplus.

Three soluble D-A type polycarbazole derivatives with different electron acceptors in the side chain, including poly[(9-(2-hexyldecyl)-9H-carbazole)-(9-(4-nitrophenyl)-9H-carbazole)] (PCz-NO₂), poly[(9-(2-hexyldecyl)-9H-carbazole)-(4-(9H-carbazole-9-yl)benzaldehyde)] (PCz-CHO), and poly[(9-(2-hexyldecyl)-9H-carbazole)-(4-(9H-carbazole-9-yl)benzonitrile)] (PCz-CN), were synthesized through the Suzuki coupling reaction. These polymers-based electronic devices with a configuration of Al (200 nm)/polymer (90 nm)/Indium-Tin Oxide (ITO) had representative bistable elec. switching behavior and non-volatile write-once read-many-times (WORM) memory performance. When the optical bandgap of conjugated polymer was increased (2.26 Ev (PCz-NO₂)→2.79 eV(PCz-CHO)→3.20 eV(PCz-CN)), the threshold voltage of the corresponding electronic device gradually increased (-1.70 V→-1.81 V→-1.89 V), whereas the ON/OFF current ratio was changed from 6.63 × 10⁴ for PCz-NO₂ to 4.08 × 10⁴ for PCz-CHO and to 5. 68 × 10³ for PCz-CN. Among these three derivatives, PCz-CN exhibited the biggest turn-on voltage and the lowest ON/OFF current ratio.

Gongneng Gaofenzi Xuebao published new progress about 373389-97-0. 373389-97-0 belongs to nitriles-buliding-blocks, auxiliary class OLED Materials,Red Fluorescence Dopants, name is 4-(3,6-Dibromo-9H-carbazol-9-yl)benzonitrile, and the molecular formula is C19H10Br2N2, COA of Formula: C19H10Br2N2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Song, Yan-ru published the artcileHPLC determination of 2-cyanobenzyl chloride, Application In Synthesis of 612-13-5, the publication is Yinran Zhuji (2007), 24(3), 45-46, database is CAplus.

Cyanobenzyl chloride content was determined by HPLC with SHIMPACK CLC ODS column (5 μm, 150 mm × 6.0 mm), UV detector (detection wave length 230 nm) and a mobile phase of MeOH and H₂O (50:50 V/V, adjusted to pH 3.0 with H₃PO₄). The linear range for 2-cyanobenzyl chloride determination was 0.15-0.80 mg/mL with γ of 0.999 9 (n = 6) and average recovery of 99.8%. The method was exact and simple, and could be used for controlling the 2-cyanobenzyl chloride quality.

Yinran Zhuji published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C6H3ClFNO2, Application In Synthesis of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Bai, Xueqian published the artcileSynthesis, antimicrobial activities, and molecular docking studies of dihydrotriazine derivatives bearing a quinoline moiety, Computed Properties of 612-13-5, the publication is Chemistry & Biodiversity (2019), 16(6), n/a, database is CAplus and MEDLINE.

In this article, three series of dihydrotriazine derivatives bearing a quinoline moiety (5a, 5b, 8a-8c, and 9a-9m) have been designed, synthesized, and evaluated as antibacterial agents. Compounds 8a-8c were found to be the most potent of all of the compounds tested with an MIC value of 1 μg/mL against several Gram-pos. (S. aureus 4220 and MRSA CCARM 3506) and Gram-neg. (E. coli 1924) strains of bacteria. In addition, 3-[4-amino-6-(phenethylamino)-2,5-dihydro-1,3,5-triazin-2-yl)-6-[(3-chlorobenzyl)oxy]quinolin-2-ol (8a) showed potent inhibitory activity (MIC=2 μg/mL) against Pseudomonas aeruginosa 2742, indicating that its antibacterial spectrum is similar to those of the pos. controls gatifloxacin and moxifloxacin. Structure-activity relationships (SAR) analyses and docking studies implicated the dihydrotriazine group in increasing the antimicrobial potency of the quinoline compounds In vitro enzyme study implied that compound 8a also displayed DHFR inhibition.

Chemistry & Biodiversity published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Computed Properties of 612-13-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Jeong, Susan published the artcileMacrocyclic Triarylethylenes via Heck Endocyclization: A System Relevant to Diazonamide Synthesis, COA of Formula: C10H11N3O3S, the publication is Journal of Organic Chemistry (1998), 63(24), 8640-8641, database is CAplus.

The author’s approach the preparation of diazonamide A (I) synthesis is described. Initial results show that Heck endocyclization can form highly functionalized lactam rings containing an imbedded 1,2-diaryl-1-(5-oxazolyl)ethylene. Thus, cross-coupling of vinylstannane II (PMB = p-methoxybenzyl) with functionalized oxazole III (prepared in 2 steps from Boc-Val-OH and aminomalononitrile tosylate) gave phenol IV in 89% yield after deprotection. Peptide coupling of IV with a protected O-benzyl-3-iodotyrosine derivative, followed by Pd-catalyzed macrocyclization gave macrocycle V, which contains the diazonamide AEF ring system.

Journal of Organic Chemistry published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, COA of Formula: C10H11N3O3S.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Chen, Chaonan published the artcileSynthesis and biological activity of substituted 1,2,4-triazolo[1,5-c]pyrimidine derivatives, Name: 2-(Chloromethyl)benzonitrile, the publication is Youji Huaxue (2009), 29(2), 245-251, database is CAplus.

A method for the synthesis of the title compounds is reported here. Several 2-(benzyloxy)-7-chloro-5-(methylthio)[1,2,4]triazolo[1,5-c]pyrimidine derivatives and 2-phenoxy[1,2,4]triazolo[1,5-c]pyrimidine derivatives were designed and synthesized using substituted 4-(hydrazinyl)pyrimidine as starting material. All compounds were confirmed by elemental anal., MS, NMR. A preliminary bioassay indicated that some compounds display good herbicidal and fungicidal activity.

Youji Huaxue published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Name: 2-(Chloromethyl)benzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Zhang, Ming-Liang published the artcileAsymmetric Michael reaction of arylacetyl phosphonates to nitroalkenes with bifunctional amine-thiourea catalyst bearing multiple-hydrogen-bond donor: efficient construction of chiral α-substituted carboxylic ester compounds, Application In Synthesis of 5153-73-1, the publication is Tetrahedron (2016), 72(21), 2677-2682, database is CAplus.

Catalytic asym. Michael addition of arylacetyl phosphonates to nitroalkenes was achieved with a chiral bifunctional amine-thiourea bearing a multiple-hydrogen-bond donor as a catalyst. A range of α-substituted carboxylic ester compounds with contiguous tertiary stereocenters could be smoothly obtained in good yields (up to 85%) and with high to excellent diastereo- and enantioselectivities (up to >99:1 dr and 95% ee). The large scale experiment and facile synthesis of a chiral γ-butyrolactam also were demonstrated.

Tetrahedron published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C14H22O2, Application In Synthesis of 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Rosowsky, Andre published the artcileMethotrexate analogs. 4. 7-Methyl derivatives of methotrexate and dichloromethotrexate. New synthesis and some biological studies, HPLC of Formula: 5098-14-6, the publication is Journal of Medicinal Chemistry (1974), 17(12), 1308-11, database is CAplus and MEDLINE.

Conversion of methotrexate (I) [59-05-2] and 3′,5′-dichloromethotrexate (II) [528-74-5] to their 7-methyl analogs III [35190-25-1] and IV [53729-18-3], resp., to prevent metabolism in vivo to the inactive 7-hydroxy derivatives resulted in marked loss of antileukemic activity in mice and in vitro and loss of inhibitory potency against purified dihydrofolate reductase [9002-03-3] from Lactobacillus casei and L1210-FR8 tumor. The lack of antitumor activity presumably resulted from impaired enzyme binding. III was prepared from 2-amino-5-chloromethyl-3-cyano-6-methylpyrazine 1-oxide [53661-20-4] and diethyl N-(p-N-methylaminobenzoyl)glutamate [2378-95-2] by the method of E. C. Taylor, et al. (1973).

Journal of Medicinal Chemistry published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, HPLC of Formula: 5098-14-6.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Shen, Yan published the artcileCopper-catalyzed direct C-H arylation of pyridine N-oxides with arylboronic esters: one-pot synthesis of 2-arylpyridines, HPLC of Formula: 214360-44-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2014), 50(33), 4292-4295, database is CAplus and MEDLINE.

The first example of the copper-catalyzed direct C-H arylation of pyridine N-oxides with arylboronic esters has been developed, leading to a wide range of 2-arylpyridines in a one-pot synthesis with moderate to good yields without an addnl. reductant. This transformation allows for rapid access to a variety of 2-arylpyridines using an inexpensive catalytic system that would be more difficult to access with traditional methods. Thus, this method represents a simple and practical procedure to access 2-arylpyridines.

Chemical Communications (Cambridge, United Kingdom) published new progress about 214360-44-8. 214360-44-8 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile, and the molecular formula is C44H28ClFeN4, HPLC of Formula: 214360-44-8.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Chang, Dan published the artcileMetal-Free Synthesis and Photophysical Properties of 1,2,4-Triarylpyrroles, HPLC of Formula: 5153-73-1, the publication is Journal of Organic Chemistry (2021), 86(1), 110-127, database is CAplus and MEDLINE.

A three-component reaction has been developed for the construction of multiaryl-substituted pyrrole derivatives from arylketones, amines, and nitrovinylarenes under metal-free conditions. Hence, homologous 1,2,4-triaryl-substituted pyrrole products were obtained in good to high yields. Furthermore, 2,3,5-triaryl-substituted pyrroles were selectively formed in the absence of nitrovinylarenes. The photophys. properties of some pyrrole products have been investigated to show good aggregation-induced emission (AIE) activity.

Journal of Organic Chemistry published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, HPLC of Formula: 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Shey, Chun Feng published the artcileSynthesis of 2,4-diamino-6-substituted pteridine, Product Details of C10H11N3O3S, the publication is Shida Xuebao (Taipei) (1984), 631-43, database is CAplus.

Title compounds I (R = Cl, OH), intermediates for methotrexate, were prepared Thus, cyclocondensation of 2,4,5,6-tetraaminopyrimidine with CO(CH₂OH)₂ gave I (R = OH) whereas cyclocondensation of 2-amino-3-cyano-5-chloromethylpyrazine with guanidine gave I (R = Cl).

Shida Xuebao (Taipei) published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C25H47NO8, Product Details of C10H11N3O3S.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts