Author: Jessica.F

Challa, Prathap published the artcileCoupling of CH3OH and CO2 with 2-cyanopyridine for enhanced yields of dimethyl carbonate over ZnO-CeO2 catalyst, Safety of Picolinonitrile, the main research area is methanol carbon dioxide cyanopyridine dimethyl carbonate.

The present work is aimed to produce di-Me carbonate by coupling of CH3OH and CO2 with 2-cyanopyridine over ZnO-CeO2 catalysts prepared by co-precipitation method. These catalysts were characterized by XRD, TEM, UV-Vis DRS, BET surface area, CO2 and NH3-TPD techniques and applied for the titled reaction. Among the investigated catalysts 10ZnO-90CeO2 catalyst with CeO2 crystallite size 8.0 nm exhibited 96% conversion of methanol with 99% selectivity to di-Me carbonate. The superior catalytic activity is a unified effect of crystalline size of CeO2 and presence of an optimum number of acidic and basic sites. This protocol offers enhanced conversion of methanol with the simultaneous conversion of 2-cyanopyridine into 2-picolinamide by removing water mols. formed in the reaction.

Journal of Chemical Sciences (Berlin, Germany) published new progress about Acidity. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dong, Yansong published the artcileA General Strategy for Macrotheranostic Prodrug Activation: Synergy between the Acidic Tumor Microenvironment and Bioorthogonal Chemistry, Quality Control of 100-70-9, the main research area is prodrug tumor pH imaging; bioorthogonal chemistry; cancer; drug delivery; photodynamic therapy; self-assembly.

Prodrugs activated by endogenous stimuli face the problem of tumor heterogeneity. Bioorthogonal prodrug activation that utilizes an exogenous click reaction has the potential to solve this problem, but most of the strategies currently used rely on the presence of endogenous receptors or overexpressed enzymes. We herein integrate the acidic, extracellular microenvironment of a tumor and a click reaction as a general strategy for prodrug activation. This was achieved by using a tumor pH-responsive polymer containing tetrazine groups, which formed unreactive micelles in the blood but disassembled in response to tumor pH. The vinyl ether group on the macrotheranostic prodrug (CyPVE) is activated by the tetrazine groups, which was confirmed by tumor-specific fluorescence activation and phototoxicity restoration. Therefore, the bioorthogonal reactions in the context of the ubiquitous acidic tumor microenvironment can provide a general strategy for bioorthogonal prodrug activation.

Angewandte Chemie, International Edition published new progress about Acidity. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Senapati, Rabinarayan published the artcileA Versatile VMPO Catalyst Prepared In Situ for Oxidative Ammonolysis of Isomeric Picolines and Xylenes, Related Products of nitriles-buliding-blocks, the main research area is picoline xylene oxidative ammonolysis vanadomolybdophosphoric acid supported titania catalyst.

The V2O5-MoO3-P2O5 (VMPO) catalyst has been prepared in situ by thermal decomposition of vanado-molybdophosphoric acid (PMoV) on TiO2 support at 475°C. The TiO2 supported VMPO catalysts are characterized by FT-IR, XRD, BET surface area, NH3-TPD, and H2-TPR. Morphol. of the catalyst has been studied by TEM. The accumulated data indicate decomposition of PMoV and presence of phosphate and pyrophosphate phases of molybdenum and vanadium after calcination. TPD and TPR studies exhibit the moderate acidity and presence of V4+ in the material, resp. The VMPO catalyst has been used for ammoxidation of six different compounds including three isomeric picolines and three isomeric xylenes to the corresponding nitriles with the yield of 90-96%.

Russian Journal of General Chemistry published new progress about Acidity. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Senapati, Rabinarayan published the artcileA Versatile VMPO Catalyst Prepared In Situ for Oxidative Ammonolysis of Isomeric Picolines and Xylenes, Recommanded Product: Picolinonitrile, the main research area is picoline xylene oxidative ammonolysis vanadomolybdophosphoric acid supported titania catalyst.

The V2O5-MoO3-P2O5 (VMPO) catalyst has been prepared in situ by thermal decomposition of vanado-molybdophosphoric acid (PMoV) on TiO2 support at 475°C. The TiO2 supported VMPO catalysts are characterized by FT-IR, XRD, BET surface area, NH3-TPD, and H2-TPR. Morphol. of the catalyst has been studied by TEM. The accumulated data indicate decomposition of PMoV and presence of phosphate and pyrophosphate phases of molybdenum and vanadium after calcination. TPD and TPR studies exhibit the moderate acidity and presence of V4+ in the material, resp. The VMPO catalyst has been used for ammoxidation of six different compounds including three isomeric picolines and three isomeric xylenes to the corresponding nitriles with the yield of 90-96%.

Russian Journal of General Chemistry published new progress about Acidity. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Procopiou, Panayiotis A. published the artcileSynthesis and Structure-Activity Relationships of Indazole Arylsulfonamides as Allosteric CC-Chemokine Receptor 4 (CCR4) Antagonists, Computed Properties of 221202-34-2, the main research area is indazole arylsulfonamide allosteric CC chemokine receptor 4 antagonist preparation; structure activity relationship solubility clearance human CCR4 antagonist; crystal mol structure indazole thiophenesulfonamide.

A series of indazole arylsulfonamides were synthesized and examined as human CCR4 antagonists. Methoxy- or hydroxyl- containing groups were the more potent indazole C4 substituents. Only small groups were tolerated at C5, C6, or C7, with the C6 analogs being preferred. The most potent N3-substituent was 5-chlorothiophene-2-sulfonamide. N1 meta-substituted benzyl groups possessing an α-amino-3-[(methylamino)acyl]- group were the most potent N1-substituents. Strongly basic amino groups had low oral absorption in vivo. Less basic analogs, such as morpholines, had good oral absorption; however, they also had high clearance. The most potent compound with high absorption in two species was analog I (GSK2239633A), which was selected for further development. Aryl sulfonamide antagonists bind to CCR4 at an intracellular allosteric site denoted site II. X-ray diffraction studies on two indazole sulfonamide fragments suggested the presence of an important intramol. interaction in the active conformation.

Journal of Medicinal Chemistry published new progress about Acidity. 221202-34-2 belongs to class nitriles-buliding-blocks, name is 2,3-Difluoro-6-methoxybenzonitrile, and the molecular formula is C8H5F2NO, Computed Properties of 221202-34-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kanaoka, Yuichi published the artcilePolyphosphate ester as a synthetic agent. XII. Convenient synthesis of nitriles by the dehydration of amides with PPE, Application of 2,3-Dimethoxybenzonitrile, the main research area is polyphosphate ester synthesis benzonitrile; benzonitrile polyphosphate ester synthesis; naphthonitrile polyphosphate ester synthesis; furonitrile polyphosphate ester synthesis; nicotinonitrile polyphosphate ester synthesis; cyano cyclohexane polyphosphate ester synthesis; cyclopentane cyano polyphosphate ester synthesis; nitrile benzo polyphosphate ester synthesis.

Nitriles were prepared in improved yields by the dehydration of amides with PPE, prepared from P2O5 and Et2O. Thus, a solution of BzNH2 and PPE in CHCl3 was refluxed 2 hr to give 87% PhCN. m-Nitrobenzonitrile, p-nitrobenzonitrile, o-chlorobenzonitrile, m-hydroxybenzonitrile, p-hydroxybenzonitrile, m-methoxybenzonitrile, p-methoxybenzonitrile, 2,3-dimethoxybenzonitrile, β-naphthonitrile, cyclopentanecarbonitrile, cyclohexanecarbonitrile, phenylacetonitrile, 2-furonitrile, nicotinonitrile, and isonicoinonitrile, were similarly prepared, but 2-furancarboxamide resisted dehydration. The primary amides were prepared by ammonolysis of the corresponding acid chlorides.

Chemical & Pharmaceutical Bulletin published new progress about Nitriles. 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Application of 2,3-Dimethoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Feskov, Serguei V. published the artcileMagnetic field effect on ion pair dynamics upon bimolecular photoinduced electron transfer in solution, Formula: C8H4N2, the main research area is magnetic field ion pair dynamics bimol photoinduced electron transfer.

The dynamics of the ion pairs produced upon fluorescence quenching of the electron donor 9,10-dimethylanthracene (DMeA) by phthalonitrile were studied in MeCN and THF using transient absorption spectroscopy. Charge recombination to both the neutral ground state and the triplet excited state of DMeA is observed in both solvents. The relative efficiency of the triplet recombination pathway decreases substantially in the presence of an external magnetic field. These results were analyzed theor. within the differential encounter theory, with the spin conversion of the geminate ion pairs described as a coherent process driven by the hyperfine interaction. The early temporal evolution of ion pair and triplet state populations with and without magnetic field could be well reproduced in MeCN, but not in THF where fluorescence quenching involves the formation of an exciplex. A description of the spin conversion in terms of rates, i.e., incoherent spin transitions, leads to an overestimation of the magnetic field effect. (c) 2019 American Institute of Physics.

Journal of Chemical Physics published new progress about Exciplex. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chattopadhyay, Purnesh published the artcilePolyol-Assisted Synthesis of Copper Particles, Formula: C8H4N2, the main research area is polyol assisted copper particle.

Copper colloids typically demonstrate excellent catalytic and elec. properties, but their synthetic approaches lag behind their more expensive cousins. In this manuscript we investigate the synthesis of Cu colloids using a polyol-based method. We employ phthalonitrile as an additive, leading to competing reactions during the nucleation step and finally resulting in distinct sizes and properties of the copper particles. Even though during the polyol synthesis, the copper particles are partially protected from the high tendency of copper to oxidize, further treatment leads to the formation of a thin passivating and semiconducting CuxO layer. CuxO is known to be a visible light photocatalyst. We therefore investigate the size-dependent (photo)catalytic activity of these colloids using rhodamine B (RhB) as a model organic pollutant. Following asymmetrization via deposition of a thin Au layer on one hemisphere, we also demonstrate the applicability as a photocatalytic micromotor.

Journal of Physical Chemistry C published new progress about Colloids. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hu, Yong-Xu published the artcileNovel Ir(III) complexes ligated with 2-(2,6-difluoropyridin-3-yl)benzo[d]thiazole for highly efficient OLEDs with mild efficiency roll-off, Quality Control of 100-70-9, the main research area is iridium complex ligated difluoropyridinylbenzothiazole OLED efficiency.

2-Phenylbenzothiazole-based Ir(III) complex [(bt)2Ir(acac)] is a class of typical yellow phosphorescence material, which has been widely used in OLEDs. However, (bt)2Ir(acac) exhibited only mild photoluminescence quantum efficiency (PLQY) of 0.26-0.28. To further improve the luminous efficiency of benzothiazole-based Ir(III) complex and then boost the corresponding electroluminescent performance, (fpbt)2Ir(pic) and (fpbt)2Ir(tftp) were successfully synthesized, where 2-(2,6-difluoropyridin-3-yl)benzo[d]thiazole (fpbt) was applied as C∩N main ligand, and 2-pyridine carboxylic acid (pic), 2-(3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)pyridine (tftp) acted as different auxiliary ligands. Both (fpbt)2Ir(pic) and (fpbt)2Ir(tftp) presented excellent PLQYs (0.93-0.95) and high thermostability (330-360 °C). The vacuum-deposited devices following the architecture of ITO/TAPC/CBP: dopant/TPBi/Liq/Al demonstrated prominent performances. Of them, (fpbt)2Ir(pic)-doped OLEDs exhibited better efficiencies of 20.6%, 68.8 cd A-1, and 40.8 l m W-1 while maintaining very mild efficiency roll-off. Such outstanding electrophosphorescent performances were further investigated, which was probably attributed to the following factors: (1) high PLQY; (2) good electron mobility; (3) uniform film-forming property.

Dyes and Pigments published new progress about Band gap. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kumar, Deepak published the artcileSyntheses and characterizations of calcium and strontium based coordination compounds with the 5-(2-pyridyl)tetrazolate ligand, respectively exhibiting extended 1 D and 2 D structures, SDS of cas: 100-70-9, the main research area is calcium strontium pyridyltetrazolate complex preparation crystal structure luminescence; thermal stability calcium strontium pyridyltetrazolate complex.

Coordination compounds of calcium and strontium with 5-(2-pyridyl)tetrazolate ligand (2-PTZ) were obtained by the reactions of the resp. metal nitrates with 2-cyanopyridine, 2-cyanoacetamide and sodium azide in aqueous solutions Both the complexes have similar composition i.e. [M(2-PTZ)2(H2O)4]n.2nH2O where M = Ca(II) (1) and Sr(II) (2). The products were characterized by FTIR spectra and single-crystal x-ray diffractions. Their photoluminescences, bandgaps, and thermal properties were studied. Single crystal x-ray diffractions revealed that both 1 and 2 have distorted square anti-prismatic mol. geometries wherein the two 2-PTZ anions act as bidentate ligands by coordinating via their pyridine-N and tetrazole-N atoms. In both the mols. six water mols., of which four acting as monodentate ligands, and the remaining two in the lattices were present. The lattice H2O mols. significantly stabilized the structures through N··H··O hydrogen bonds with the 2-PTZ ligands in the structures. Compound 2 (with around 50% decomposition) shows better thermal stability than calcium-based compound 1(72% decomposition).

Journal of Molecular Structure published new progress about Band gap. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts