Author: Jessica.F

Liu, Fusheng published the artcileEfficient One Pot Capture and Conversion of CO2 into Quinazoline-2,4(1H,3H)-diones Using Triazolium-Based Ionic Liquids, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is CO quinazolinedione triazolium ionic liquid.

CO2 capture and utilization (CCU) have aroused much attention. In this paper, several novel triazolium-based ionic liquids (ILs) were developed for highly efficient transformation of CO2 into quinazoline-2,4(1H,3H)-diones. The catalytic behaviors such as the effects of IL structures and reaction parameters, catalyst recyclability, and scope of substrates were studied in detail. As compared to the reported homogeneous and heterogeneous catalysts, the [HTMG][Triz] with a tetramethylguanidine cation and a triazole anion exhibited an exceptional activity at 50°C and 1 atm CO2 without any organic solvents. On the basis of the CCU strategy, we first studied the equimolar CO2 capture by the [HTMG][Triz] and one pot conversion of activated CO2 into various quinazoline-2,4(1H,3H)-diones, and good to excellent product yields were obtained. In addition, the catalytic performance for synthesis of quinazoline-2,4(1H,3H)-dione under low concentration of CO2 using a simulated flue gas was studied. The developed triazolium-based ILs could realize simultaneous activation of CO2 and the substrates under ambient conditions, which also have been demonstrated to support the reaction mechanism well. The integrative protocol here shows great significance in the practical synthesis of quinazoline-2,4(1H,3H)-dione and their derivatives from captured CO2 waste under mild conditions. Triazolium-based ionic liquids show exceptional performance for equimolar CO2 capture and subsequent conversion into quinazoline-2,4(1H,3H)-diones under mild conditions.

ACS Sustainable Chemistry & Engineering published new progress about Flue gases. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Groen, Aaron C. published the artcileA novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly, Formula: C10H8FN, the main research area is FCPT ATPase inhibitor kinesin spindle pole assembly.

The tetrameric plus-end-directed motor, kinesin-5, is essential for bipolar spindle assembly. Small-mol. inhibitors of kinesin-5 have been important tools for investigating its function, and some are currently under evaluation as anti-cancer drugs. Most inhibitors reported to date are ‘non-competitive’ and bind to a specific site on the motor head, trapping the motor in an ADP-bound state in which it has a weak but non-zero affinity for microtubules. Here, we used a novel ATP-competitive inhibitor, FCPT, developed at Merck (USA). We found that it induced tight binding of kinesin-5 onto microtubules in vitro. Using Xenopus egg-extract spindles, we found that FCPT not only blocked poleward microtubule sliding but also selectively induced loss of microtubules at the poles of bipolar spindles (and not asters or monoasters). We also found that the spindle-pole proteins TPX2 and γ-tubulin became redistributed to the spindle equator, suggesting that proper kinesin-5 function is required for pole assembly.

Journal of Cell Science published new progress about Centrosome. 97009-67-1 belongs to class nitriles-buliding-blocks, name is 1-(4-Fluorophenyl)cyclopropanecarbonitrile, and the molecular formula is C10H8FN, Formula: C10H8FN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Vogt, Natalja published the artcileThe equilibrium molecular structure of 2-cyanopyridine from combined analysis of gas-phase electron diffraction and microwave data and results of ab-initio calculations, Synthetic Route of 100-70-9, the main research area is cyanopyridine electron diffraction microwave rotational constant equilibrium mol structure.

The gas-phase electron diffraction study of 2-cyanopyridine was carried out for the first time. Results of ab-initio structure calculations performed at the CCSD(T) level of theory agree well with the equilibrium structure determined by the electron diffraction method in combination with vibrational spectroscopy data and microwave rotational constants The deviations between them are only a few thousandths of Å units and a few tenths of degree in the bond lengths and bond angles, resp. The structure in the solid state is more different from that in the gas phase. The observed discrepancies between these structures are up to 0.02 Å and 2° in the bond lengths and bond angles, resp. The influence of the ortho-, meta- and para-cyano substituents on the geometry of pyridine ring is discussed. The pyridine ring is noticeably distorted due to cyano substituents. The Cipso-N and/or Cipso-C bond lengths are elongated both in 2-CNP and 4-CNP by 0.004 Å in comparison to those in pyridine, whereas the Cipso-C bond lengths are increased by 0.005 and 0.009 Å in 3-CNP.

Structural Chemistry published new progress about Bond angle. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Koppala, Srinivasarao published the artcileDevelopment and validation of a novel stability-indicating RP-HPLC method for the simultaneous determination of related substances of ketoprofen and omeprazole in combined capsule dosage form, Name: 2-(3-Benzoylphenyl)propanenitrile, the main research area is ketoprofen omeprazole capsule RP HPLC.

A novel, simple, sensitive, selective and reproducible stability-indicating high performance liquid chromatog. method was developed for the quant. determination of degradation products and process-related impurities of ketoprofen (KET) and omeprazole (OMZ) in combined oral solid dosage form. Chromatog. separation was achieved on a Phenomenex Luna C18 (2) column (150 × 4.6 mm, 5 μm) under gradient elution by using a binary mixture of potassium dihydrogen phosphate buffer and acetonitrile at a flow rate of 0.8 mL/min. Chromatogram was monitored at 233 nm for KET impurities and at 305 nm for OMZ impurities using a dual wavelength UV detector. Resolution for KET and OMZ and 14 impurities was found to be >1.5 for any pair of components. Typical retention behaviors of impurities at various pH values were depicted graphically. To prove the stability-indicating power of the method, the drug product was subjected to hydrolytic, oxidative, photolytic, humidity and thermal stress conditions as per ICH. The developed method was validated according to the current ICH guidelines for specificity, limit of detection, limit of quantification, linearity, accuracy, precision, ruggedness and robustness.

Journal of Chromatographic Science published new progress about Acid hydrolysis. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Name: 2-(3-Benzoylphenyl)propanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Guo, Hongguang published the artcileHigh Potential of Methane Production from Coal by Fungi and Hydrogenotrophic Methanogens from Produced Water, HPLC of Formula: 91-15-6, the main research area is methane coal fungus hydrogenotrophic methanogen water bacteria organic.

Studying in situ microorganisms is essential to understand the formation of biogenic coalbed methane (CBM). Only a few studies have studied the fungi community inhabiting in coal seams although fungi degrade refractory compounds and solubilize coal and even work with methanogens to produce methane. Produced H2O was collected from Qinshui Basin and used as the source of microflora to degrade coal. The function of fungi was analyzed by inhibition of bacteria with antibiotics. The inhibition of bacteria in the microcosms significantly increased the methane yield. Fungi were more favorable to cooperate with hydrogenotrophic methanogens when bacteria were inhibited as Methanobacterium were the predominant archaea accounting for 45.98-86.98% of the sequence reads. The relatively unchanged fungal community and high volatile fatty acids (VFAs) yields (48.70-85.72%) in the presence of antibiotics might contribute to H2 production to facilitate hydrogenotrophic methanogenesis. On the contrary, the dominant methanogens in microcosms without antibiotics gradually changed from Methanobacterium (89.85%) to Methanoceta (46.19%) and finally to Methanobacterium (87.72%). The bacterial community and organic intermediates have also changed greatly over time, which can be the reason for the succession of the methanogens. Probably fungi in produced H2O can play an important role in coal biodegradation to produce VFAs and H2 that support hydrogenotrophic methanogenesis, which could be neg. impacted by the existence of bacteria.

Energy & Fuels published new progress about Acetoanaerobium. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mougeot, Romain published the artcileConvergent and Practical Synthesis of Fluorescent Triphenylamine Derivatives and Their Localization in Living Cells, Quality Control of 100-70-9, the main research area is pyridine oxazole thiazole preparation fluorescence.

In the search for new fluorescent triphenylamine (TP) derivatives, authors studied the influence of the position and substitution of diverse heterocyclic substituents. A library of 10 fluorescent triphenylamines bearing either oxazoles or thiazoles and pyridiniums, substituted at different positions has been developed. The approach is based on a convergent C-H activation reaction between pyridine-oxazoles or pyridine-thiazoles and di-iodo triphenylamine. Author’s showed that the nature and substitution pattern of the 5-membered- (oxazole, thiazole) or 6-membered heterocycle (pyridine) has a strong influence on their fluorescence properties and on their localization in living cells as they stain either the nucleus or mitochondria.

European Journal of Organic Chemistry published new progress about Fluorescent dyes. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yu, Yueh-Cheng published the artcileConceptual design, environmental, and economic evaluation of direct copolymerization process of carbon dioxide and 1,4-butanediol, Category: nitriles-buliding-blocks, the main research area is carbon dioxide butanediol copolymerization.

The routes to convert CO2 into environmentally benign materials have attracted wide attentions. In this work, an emerging process to produce poly(butylene carbonate) (or PBC) from direct copolymerization of carbon dioxide and 1,4-butanediol is firstly simulated with analyses on the CO2 emission ratio (CO2-e, in kg-CO2/kg-PBC) and yearly unit manufacturing cost of product (YUMC, in USD/kg). In order to address the issues associated with large amount of solvents used in the lab scale, two proposed scenarios including the reduction of solvent amount, and heat integration by vapor recompression cycle (VRC) were simulated. It is found that CO2-e is reduced by 82.0% (from 30.06 to 5.42) when the solvent amount is reduced to 10%, and another 19.9% reduction in CO2-e (to 4.34) when applying the VRC. YUMCs are reduced by ca. 68% for both proposed scenarios (from 5.62 to ca. 1.8). The findings reported in this study may prove informative for developing CO2 conversion technologies from lab scale to industrial scale.

Journal of the Taiwan Institute of Chemical Engineers published new progress about Copolymerization. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yu, Bin published the artcileDesign, Synthesis, and Evaluation of the Antifungal Activity of Novel Pyrazole-Thiazole Carboxamides as Succinate Dehydrogenase Inhibitors, HPLC of Formula: 1885-29-6, the main research area is pyrazole thiazole carboxamide derivative preparation succinate dehydrogenase inhibitor antifungal; fungicidal activity; molecular docking; structure−activity relationships; succinate dehydrogenase inhibitors.

Succinate dehydrogenase (SDH) is regarded as a promising target for fungicide discovery. To continue our ongoing studies on the discovery of novel SDH inhibitors as fungicides, novel pyrazole-thiazole carboxamides were designed, synthesized, and evaluated for their antifungal activity. The results indicated that compounds 9ac, 9bf, and 9cb showed excellent in vitro activities against Rhizoctonia cerealis with EC50 values from 1.1 to 4.9 mg/L, superior to that of the com. fungicide thifluzamide (EC50 = 23.1 mg/L). Compound 9cd (EC50 = 0.8 mg/L) was far more active than thifluzamide (EC50 = 4.9 mg/L) against Sclerotinia sclerotiorum. Compound 9ac exhibited promising in vivo activity against Rhizoctonia solani (90% at 10 mg/L), which was better than that of thifluzamide (80% at 10 mg/L). The field experiment showed that compound 9ac had 74.4% efficacy against Rhizoctonia solani on the 15th day after two consecutive sprayings at an application rate of 4.80 g a.i./667 m2, which was close to that of thifluzamide (83.3%). Furthermore, mol. docking explained the possible binding mode of compound 9ac in the RcSDH active site. Our studies indicated that the pyrazole-thiazole carboxamide hybrid is a new scaffold of SDH inhibitors.

Journal of Agricultural and Food Chemistry published new progress about Botrytis cinerea. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yang, Xulin published the artcileDesigning phthalonitrile/hydroxyl compound systems for high performance CFRP composites, HPLC of Formula: 91-15-6, the main research area is phthalonitrile hydroxyl compound system carbon fiber reinforced polymer composite.

High mech. residues at/after elevated temperatures are basic prerequisites for the engineering applications of carbon fiber reinforced polymer (CFRP) composites in special fields like aerospace. In this study, phthalonitrile (PNP) copolymers based on hydroxyl compounds of BP monomer, PEP and BZCN resin were designed and their curing behavior and processability were investigated for realizing the corresponding CFRP composites. High temperature mech. performances of PNP/hydroxyl compound/CF composites under instantaneous and non-instantaneous states are systematically assessed. At 300°C, PNP/hydroxyl compounds/CF composite showed a retention rate of tensile, compressive, flexural strength and flexural modulus higher than 35%, 95%, 80% and 90%, resp. After 300°C/50 h thermal aging, their flexural properties show no obvious attenuation. Even after being aged at 350°C for 50 h, the residue of flexural modulus is above 90% while that of flexural strength is over 60%. The mass residue of PNP/hydroxyl compounds/CF composites were all higher than 98% and 90% after aging at 300°C and 350°C for 50 h. PNP/hydroxyl compounds/CF composites, with the excellent comprehensive mech. properties, can be used as high performance engineering materials.

Materials Research Express published new progress about Bending strength. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Zhaoyang published the artcileMechanisms and reaction conditions of CO2 with o-aminobenzonitrile for the synthesis of quinazoline-2,4-dione, Category: nitriles-buliding-blocks, the main research area is review carbon dioxide aminobenzonitrile quinazolinedione reaction condition.

Quinazoline-2,4(1H,3H)-dione derivatives are key intermediates in pharmaceutical, biol. and chem. fields. To avoid the use of toxic carbonylation reagents such as phosgene, carbon monoxide and potassium cyanate, green synthesis methods for preparing quinazolindiones via the reaction of o-aminobenzonitrile with CO2 are developed. In this review, the factors such as reaction medium, catalyst and reaction temperature that influence the reaction of o-aminobenzonitrile with CO2 are systematically discussed. The protic solvent is favorable for the nitrile group as the initial reaction site to react with CO2. In contrast, the reactivity of the nitrile group and amino group of o-aminobenzonitrile could hardly be affected by aprotic solvent. Moreover, the reaction is also strongly affected by the catalyst, which is evaluated by the basicity and nucleophilicity of the catalyst. Specifically, the basicity mainly affects the activation of the amino group in the o-aminobenzonitrile substrate, whereas the nucleophilicity primarily impacts the formation of the CO2 activated state. The similarities and differences of different catalysts such as organic bases, inorganic bases, ionic liquids and supported catalysts in specific reaction pathways are also discussed in this review. In addition, the formation of isocyanate intermediate in the rearrangement process is significantly affected by the reaction temperature The quinazolindione could be easily formed from the isocyanate intermediate, isomerized from the cyclic carbamate, under high reaction temperature Furthermore, the quinazolindione could be formed directly by the isomerized cyclic carbamate under low reaction temperature

Journal of CO2 Utilization published new progress about Aprotic solvents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts