Author: Jessica.F

Shakya, Bhushan published the artcile2-Pyridineformamide N(4)-ring incorporated thiosemicarbazones inhibit MCF-7 cells by inhibiting JNK pathway, Computed Properties of 100-70-9, the main research area is neoplasm antitumor 2 pyridineformamide thiosemicarbazone JNK pathway; 2-Pyridineformamide thiosemicarbazone; A375; A431; Cell viability; HeLa; MCF-7.

In an effort to develop a more potent anticancer therapeutic agent, a series of 2-pyridineformamide thiosemicarbazones (I) (R = H, 4-CH3, 5-F, 6-CH3; heterocycle = pyrrolidine, piperidine, morpholine, thiomorpholine, azepane, 1-(2-pyridinyl)-piperazine) have been synthesized and evaluated for their anti-cancer activities against the cancer cells MCF-7 (breast cancer cell line), A-431 and A375 (epidermoid carcinoma cell line), and HeLa (cervical cancer cell line) using MTT assay. All these 2-pyridineformamide thiosemicarbazones exhibited anti-proliferative activities towards these cell lines. 5FAmPyrr(II) possess most profound effects against MCF-7 cells with IC50 of 0.9 μM. In flow cytometry using Propidium Iodide, II was found to induce cell death significantly in a dose dependent manner (100 nM-3 μM) and inhibited colony formation of MCF-7 cells. This compound induced pro-apoptotic protein Bax and inhibited anti apoptotic protein Bcl-2 as well as both c-Jun and Jun N-terminal kinase (abbreviated as JNK) in concentration dependent manner. Further pro-caspase 3 and PARP were inhibited by II at concentration of 3 μM. The results suggest that II exhibit anticancer potency and induced cell death by inhibiting MAPK signaling and inducing intrinsic apoptotic pathway. All these indicate that 2-pyridineformamide thiosemicarbazones could be developed as future therapeutics agents to treat cancer.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Potikha, L. M. published the artcileCondensed isoquinolines. 22. Synthesis and properties of 6,11-dihydro-13H-isoquino[3,2-b]quinazolin-13-ones, Quality Control of 73217-11-5, the main research area is haloanthranilic acid heterocyclization bromomethylphenylacetonitrile; isoquinolinium bromide halophenyl preparation heterocyclization; isoquinoquinazolinone derivative preparation rearrangement.

The reaction of 3-haloanthranilic acids with [o-(bromomethyl)phenyl]acetonitrile gave 2-(2-carboxy-6-halophenyl)-1,4-dihydro-3(2H)-isoquinolinium bromides. (2-Chlorophenyl)isoquinolinium bromides are readily converted to 4-R-6,11-dihydro-13H-isoquino[3,2-b]quinazolin-13-ones, e.g., I, by heating >145°, but (2,4-dibromophenyl)isoquinolinium bromide only on fusing with anthranilic acid. The effect of the nature and position of substituents in the quinazoline fragment of 7,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-ones, e.g., II, on the rate of rearrangement to 6,11-dihydro-13H-isoquino[3,2-b]quinazol-13-ones has been studied. The oxidation and borohydride reduction of 6,11-dihydro-13H-isoquino[3,2-b]quinazol-13-ones has been studied.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Heterocyclization. 73217-11-5 belongs to class nitriles-buliding-blocks, name is 2-(2-(Bromomethyl)phenyl)acetonitrile, and the molecular formula is C9H8BrN, Quality Control of 73217-11-5.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Xiao-Meng published the artcile4-(3-Fluoro-4-methoxyphenyl)-1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-imidazole, Application of a-Tosyl-(4-methoxybenzyl) isocyanide, the main research area is crystal structure fluoromethoxyphenylmethoxyphenyltrimethoxyphenylimidazole; mol structure fluoromethoxyphenylmethoxyphenyltrimethoxyphenylimidazole; imidazole fluoromethoxyphenylmethoxyphenyltrimethoxyphenyl crystal mol structure.

In 4-(3-fluoro-4-methoxyphenyl)-1-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-imidazole, C26H25FN2O5, the fluoromethoxy-, methoxy- and trimethoxy-substituted benzene rings form dihedral angles of 12.65(2), 84.15(2) and 55.67(2)°, resp., with the imidazole ring. The crystal structure is stabilized weak intermol. C-H···F and C-H···O H bonds. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, Application of a-Tosyl-(4-methoxybenzyl) isocyanide.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rozhkova, Yuliya S. published the artcileSynthesis of novel racemic 3,4-dihydroferroceno[c]pyridines via the Ritter reaction, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is dihydroferroceno pyridine preparation crystal mol structure; Ritter reaction methyl ferrocenylpropanol nitrile methansulfonic acid.

A new approach for the synthesis of functionalized racemic 3,4-dihydroferroceno[c]pyridines via the Ritter reaction of 2-methyl-1-ferrocenylpropan-1-ol with nitriles in the presence of methansulfonic acid was developed. The scope and limitations of the reaction were evaluated. Selected racemic 3,4-dihydroferroceno[c]pyridines were successfully separated by preparative HPLC on a Chiralcel OD-H column. The absolute configuration of the enantiomers was determined by x-ray crystal structure anal.

Tetrahedron Letters published new progress about Crystal structure. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rozhkova, Yuliya S. published the artcileSynthesis of novel racemic 3,4-dihydroferroceno[c]pyridines via the Ritter reaction, Related Products of nitriles-buliding-blocks, the main research area is dihydroferroceno pyridine preparation crystal mol structure; Ritter reaction methyl ferrocenylpropanol nitrile methansulfonic acid.

A new approach for the synthesis of functionalized racemic 3,4-dihydroferroceno[c]pyridines via the Ritter reaction of 2-methyl-1-ferrocenylpropan-1-ol with nitriles in the presence of methansulfonic acid was developed. The scope and limitations of the reaction were evaluated. Selected racemic 3,4-dihydroferroceno[c]pyridines were successfully separated by preparative HPLC on a Chiralcel OD-H column. The absolute configuration of the enantiomers was determined by x-ray crystal structure anal.

Tetrahedron Letters published new progress about Crystal structure. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reshma, G. published the artcileSynthesis and structure of mono and bis {1,3-bis(2-pyridylimino)isoindoline} supported 3d transition metal complexes, Synthetic Route of 91-15-6, the main research area is mono bis pyridyliminoisoindoline transition metal complex preparation; crystal mol structure cobalt bis pyridyliminoisoindoline complex; manganese iron cobalt nickel copper zinc pyridyliminoisoindoline complex preparation.

Series of homoleptic and heteroleptic 3d transition metal complexes were prepared in anal. pure form and high yield, by reacting appropriate metal precursors with 1,3-bis(2-pyridylimino)isoindolate (BPIH) ligand under suitable reaction conditions. The complexes were characterized by various spectro-anal. techniques, including IR, UV, NMR, ESI Mass and x-ray crystal anal. A distorted octahedral structure containing two meridionally coordinating BPI ligands was assigned to all the homoleptic complexes. While, for the heteroleptic complexes, a highly distorted square pyramidal geometry, with a planar tridentate BPI ligand coordinating to the metal center along with chloro and aqua ligands was assigned. Considering the unique structural features of the complexes, potential catalytic applications are envisaged.

Journal of Molecular Structure published new progress about Crystal structure. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Synthetic Route of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhan, Yong published the artcileMechanofluorochromism based on BOPIM complexes: The effect of substituents and regulation of the direction of the emission color changes, Related Products of nitriles-buliding-blocks, the main research area is preparation boron pyridyl imidazole complex; crystal mol structure boron pyridyl imidazole complex; mechanofluorochromism boron pyridyl imidazole complex; thermal decomposition boron pyridyl imidazole complex.

Novel boron 2-(2′-pyridyl)imidazole (BOPIM) complexes T1, T2 and T3 with different substituents (including bromo, tert-Bu and methoxyl) on the benzene ring of BOPIM dyes were designed and synthesized, and their optical properties in both solution and the solid state were studied and compared. The three compounds exhibited typical intramol. charge transfer (ICT) characteristics. Solvent-dependent UV-visible absorption, fluorescence emission spectra and quantum chem. calculation indicated a mol. push-pull electronic structure. Their ICT degrees increased with the sequence of T1 < T2 < T3. The anal. of the x-ray crystal structure revealed the twisted mol. conformation of BOPIM dyes. Furthermore, they showed remarkable reversible mechanofluorochromic (MFC) features under mech. force. The MFC activities could be tuned easily by changing the substituents on the BOPIM dyes. T1 exhibited emission color change from bright green to yellowish green with a spectral red shift of only 22 nm under mech. stimuli, whereas T2 and T3 gave the large spectral red shifts of 36 and 30 nm. Electronic and steric effects of the substitutes were proved playing significant roles in regulating the ICT effect and intermol. interactions. More importantly, the remarkable effect of substituents on the MFC behaviors of BOPIM dyes will provide an effective way to obtain novel high-contrast MFC dyes. Dyes and Pigments published new progress about Crystal structure. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Saha, Sayantani published the artcileCatalytic Recycling of a Th-H Bond via Single or Double Hydroboration of Inactivated Imines or Nitriles, Quality Control of 100-70-9, the main research area is metallacycle thorium amide preparation crystal mol structure catalyst hydroboration; selective dihydroboration nitrile aldimine inactivated imine nitrile hydroboration catalyst.

The catalytic activity of the metallacycle thorium amide [(Me3Si)2N]2Th[κ2-(N,C)-CH2Si(CH3)2N(SiMe3)] (Th1) is presented for the selective dihydroboration of nitriles (-CN) with pinacolborane (HBpin). Using significantly low catalyst loading (0.1 mol %), the dihydroborated amines were achieved by the hydroboration of the -CN triple bond attached with aromatic, aliphatic, and heteroatom backbones with high turnover frequency (TOF) as compared to all the reported homogeneous metal catalysts in this reaction. In addition, for aldimines (-C=N-), the hydroboration precatalyst Th2 has been synthesized by the protonolysis of a seven-membered N-heterocyclic iminato ligand (LH) and Th1. The Th2 crystal structure and its performance in the synthesis of hydroborated secondary amine are also here presented. Detailed kinetic studies and thermodn. and stoichiometric experiments provided us with cumulative evidence supporting the proposed mechanism for the aforementioned reactions.

ACS Catalysis published new progress about Crystal structure. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Qurban, Jihan published the artcileSynthesis, characterization and reactivity of novel pseudocyclic hypervalent iodine reagents with heteroaryl carbonyl substituents, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is heteroaryl hydroxy benzoiodaoxolium triflate preparation crystal structure oxidative reaction.

Two new hypervalent iodine reagents containing furan and thiophene moieties in addition to a carbonyl group in the vicinity of the iodine atom were synthesized and characterized. The X-ray anal. of both compounds revealed a strong intramol. contact between the carbonyl oxygen and the hypervalent iodine atom with tosylate as a counter ion. The two reagents showed a broad range of synthetic applications and proved to be versatile oxidizing agents.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mulholland, Katie D. published the artcileIridium-catalysed 3,5-bis-borylation of phthalonitrile enables access to a family of C4h octaarylphthalocyanines, Safety of Phthalonitrile, the main research area is transition metal octaarylphthalocyanine complex preparation crystal structure; NMR spectra fluorescence transition metal octaarylphthalocyanine complex; preparation arylphthalonitrile crystal structure NMR spectra.

Ir-catalyzed borylation of phthalonitrile produces both 4-(Bpin)phthalonitrile (1) and 3,5-bis(Bpin)phthalonitrile (2), which are potential divergent intermediates for the synthesis of functionalized phthalocyanines. To exemplify the utility of 2, the authors prepared a series of 3,5-bis-arylphthalonitriles that in turn undergo sterically controlled regioselective cyclotetramization to give previously unknown C4h 1,3,8,10,15,17,22,24-octaarylphthalocyanines.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Safety of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts