Author: Jessica.F

Aydin, Ali published the artcileIn-Vitro Anticancer and Antibacterial Activities of Brominated Indeno[1,2-b]qinoline Amines Supported with Molecular Docking and MCDM, Application In Synthesis of 1885-29-6, the main research area is brominated indenoqinoline amine anticancer antibacterial activity mol docking MCDM.

The present study describes mono substituted indeno[1,2-b]quinolines (3 a-c and 5) have much more antiproliferative potentials than pos. controls against A549, HeLa, MCF7 and Hep3B cell lines (IC50 values 1.1-29.6 μg/mL) and show similar cytotoxicity (14.3% to 19.8%) to cells such as controls. Moreover, the mono substituted indeno[1,2-b]quinoline amines (3 a-c and 5) exhibit significant antimicrobial activity with MIC values between 15.62 μ g/mL and 250 μg/mL. The compounds can also bind to DNA in the groove binding mode with a binding constant range of 1.1×103-1.1×105 M-1. The anticancer and antibacterial properties of compounds were confirmed with the mol. docking simulation for their pharmacokinetic. As a result, the preliminary exptl. data and a multi-criteria decision-making methodol. (MCDM) indicated that the mono substituted indeno[1,2-b]quinoline amine derivatives, especially 3 a and 5, exhibit effective pharmacol. properties. parameters and their interaction with related cells at the mol. level.

ChemistrySelect published new progress about Antibacterial agents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zheng, Bing-De published the artcileA non-aggregated zinc(II) phthalocyanine with hexadeca cations for antitumor and antibacterial photodynamic therapies, Application of Phthalonitrile, the main research area is nonaggregated zinc phthalocyanine hexadeca cation antitumor antibacterial photodynamic therapy; Antibacterial; Anticancer; Cationic zinc(II) phthalocyanine; Non-aggregation; Photodynamic therapy.

With a view to developing highly efficient photosensitizers for both antitumor and antimicrobial photodynamic therapies, herein, we reported a super cationic zinc(II) phthalocyanine (Pc4), which was prepared through the quaternization of the N, N-dimethyl-3-aminophenoxyl-hexadeca-substituted precursor Pc3. Meanwhile, two disubstituted analogs (Pc1 and Pc2) were also prepared as controls. The cationic Pc2 and Pc4 had higher photoactivities including fluorescence and singlet oxygen than the neutral counterparts Pc1 and Pc3, probably because of the inhibition of intramol. charge transfer (ICT) effect of the amino groups. With the bulky steric effect and high hydrophilicity, Pc4 presented non-aggregated behavior in aqueous solutions Therefore, it exhibited the highest in vitro photodynamic activity toward HepG2 cancer cells with an IC50 value as low as 0.04 μM. Furthermore, Pc4 showed a highly efficient in vivo PDT effect on H22 tumor-bearing mice with 98.7% tumor growth inhibition. In addition, Pc4 also exhibited an excellent in vitro and in vivo photodynamic inactivation against S. aureus. The results indicate that the non-aggregated hexadeca-cationic Pc4 could serve as a promising photosensitizer for both antitumor and antimicrobial photodynamic therapies.

Journal of Photochemistry and Photobiology, B: Biology published new progress about Antibacterial agents. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xue, Wenjie published the artcileN-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification, Computed Properties of 100-70-9, the main research area is thiadiazole hydroxy quinolone carboxamide preparation antibacterial docking pharmacokinetic antitumor; Antibacterial agent; Antibiotic resistance; DNA gyrase B; MRSA; Molecular docking.

In this study, N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamide derivatives I (R1 = Et, cyclopentyl, 3-fluorophenyl, 1,3-thiazol-4-yl, etc.; R2 = Me, Et, n-Pr) were designed and synthesized and evaluated for their antibacterial activity against S. aureus ATCC29213, which led to the identification of ten potent antibacterial agents with min. inhibitory concentration (MIC) values below 1μg/mL. Next, bacterial growth inhibition assays against a panel of drug-resistant clin. isolates, including methicillin-resistant S. aureus, and cytotoxicity assays with HepG2 and HUVEC cells were performed. One of the tested compounds named I [R1 = 1,3-thiazol-2-yl; R2 = Et] (A) showed 2 to 128-times improvement compared with vancomycin in term of antibacterial potency against the tested strains (MICs: 0.25-1μg/mL vs. 1-64μg/mL) and an optimal selective toxicity (HepG2/MRSA, 110.6 to 221.2; HUVEC/MRSA, 77.6-155.2). Further, comprehensive evaluation indicated that (A) did not induce resistance development of MRSA over 20 passages, and it has been confirmed as a bactericidal, metabolically stable, orally active antibacterial agent. More importantly, the S. aureus DNA gyrase B as its potential target is identified and a potential binding mode by mol. docking is proposed. Taken together, the present work reports the most potent derivative of this chem. series (A) and uncovers its potential target, which lays a solid foundation for further lead optimization facilitated by the structure-based drug design technique.

European Journal of Medicinal Chemistry published new progress about Antibacterial agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yi, Qiao-Yan published the artcileAnticancer and antibacterial activity in vitro evaluation of iridium(III) polypyridyl complexes, Synthetic Route of 100-70-9, the main research area is iridium polypyridyl complexes apoptosis cell cycle anticancer antibacterial; Antibacterial activity; Apoptosis; Cell cycle distribution; Iridium(III) complexes; Western blot.

Three iridium(III) polypyridyl complexes [Ir(ppy)2(PYTA)](PF6) (1) (ppy = 2-phenylpyridine), [Ir(bzq)2(PYTA)](PF6) (2) (bzq = benzo[h]quinolone) and [Ir(piq)2(PYTA)](PF6) (3) (piq = 1-phenylisoquinoline, PYTA = 2,4-diamino-6-(2′-pyridyl)-1,3,5-triazine) were synthesized and characterized by elemental anal., IR, 1H NMR and 13C NMR. The cytotoxic activity of the complexes toward cancer SGC-7901, Eca-109, A549, HeLa, HepG2, BEL-7402 and normal LO2 cell lines was investigated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Complex 3 shows the most effective on inhibiting the above cell growth among these complexes. The complexes locate at the lysosomes and mitochondria. AO/EB, Annex V and PI and comet assays indicate that the complexes can induce apoptosis in SGC-7901 cells. Intracellular ROS and mitochondrial membrane potential were examined under fluorescence microscopy. The results demonstrate that the complexes increase the intracellular ROS levels and induce a decrease in the mitochondrial membrane potential. The complexes can enhance intracellular Ca2+ concentration and cause a release of cytochrome c. The autophagy was studied using MDC staining and western blot. Complexes 1-3 can effectively inhibit the cell invasion with a concentration-dependent manner. Addnl., the complexes target tubules and inhibit the polymerization of tubules. The antimicrobial activity of the complexes against S. aureus, E. coli, Salmonella and L. monocytogenes was explored. The mechanism shows that the complexes induce apoptosis in SGC-7901 cells through ROS-mediated lysosomal-mitochondrial, targeting tubules and damage DNA pathways. Three iridium(III) complexes [Ir(N-C)2(PYTA)](PF6) (N-C = ppy, 1; bzq, 2; piq, 3) were synthesized and characterized. The anticancer activity of the complexes against SGC-7901 cells was studied by apoptosis, comet assay, autophagy, ROS, mitochondrial membrane potential, intracellular Ca2+ levels, release of cytochrome c, tubules and western blot anal. The antibacterial activity in vitro was also assayed.

JBIC, Journal of Biological Inorganic Chemistry published new progress about Antibacterial agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Onyedibe, Kenneth I. published the artcileSF5- and SCF3-substituted tetrahydroquinoline compounds as potent bactericidal agents against multidrug-resistant persister Gram-positive bacteria, SDS of cas: 1885-29-6, the main research area is pentafluorosulfanyl trifluoromethylthio substituted tetrahydroquinoline multidrug resistance; gram pos bacteria persister bactericidal agent.

Bacteria persister cells are immune to most antibiotics and hence compounds that are active against persister bacteria are needed. We screened a chem. library of SF5- and SCF3-substituted tetrahydroquinoline compounds, synthesized via the Povarov reaction, for antibacterial activity and identified active compounds that displayed good activities against many Gram-pos. bacteria, including persisters. The most potent of these compounds, HSD1835, inhibited the growth of drug-resistant Gram-pos. bacterial pathogens (including clin. strains) at concentrations ranging from 1 μg mL-1 to 4 μg mL-1. Several of the SCF3- and SF5-containing compounds were active against methicillin-resistant Staphylococcus aureus (MRSA) and against the two most fatal strains of vancomycin-resistant Enterococcus (VRE), VRE faecalis and VRE faecium. The compounds showed bactericidal activity against stationary phase persister MRSA in time-kill assays. Mechanistic studies showed that HSD1835 acts by disrupting bacterial membranes. SEM (SEM) was used to confirm bacterial membrane disruption. Interestingly, in a 30 day serial exposure experiment, MRSA remained susceptible to low-dose HSD1835 while resistance to ciprofloxacin and mupirocin emerged by day 10. Analogs of HSD1835, which did not bear the SF5 or SCF3 moieties, were inactive against bacteria. Recent reports (G.A.Naclerio, N.S.Abutaleb, K.I.Onyedibe, M.N.Seleem and H.O.Sintim, RSC Med.Chem. 2020, 11, 102-110 and G.A.Naclerio, N.S.Abutaleb, D.Li, M.N.Seleem and H.O.Sintim, J.Med.Chem. 2020, 63(20), 11934-11944) also demonstrated that adding the SF5 or SCF3 groups to a different scaffold (oxadiazoles) enhanced the antibacterial properties of the compounds, so it appears that these groups are privileged moieties that enhance the antimicrobial activities of compounds Naclerio, N. S. Abutaleb, D. Li, M. N. Seleem and H. O. Sintim, J. Med. Chem. 2020, 63(20), (11934-11944) also demonstrated that adding the SF5 or SCF3 groups to a different scaffold (oxadiazoles) enhanced the antibacterial properties of the compounds, so it appears that these groups are privileged moieties that enhance the antimicrobial activities of compounds

RSC Medicinal Chemistry published new progress about Antibacterial agents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Qian, Deyun published the artcileLigand-Controlled Regiodivergent Hydroalkylation of Pyrrolines, Computed Properties of 100-70-9, the main research area is pyridine oxazoline ligand preparation; alkyalated pyrrolidine preparation regioselective; pyrroline halide hydroalkylation pyridine oxazoline ligand nickel catalyst; alkenes; heterocycles; hydroalkylation; nickel; reaction mechanisms.

Two series of C-alkylated pyrrolidines I [R = Boc, Cbz; R1 = i-Pr, cyclopentyl, indol-1-yl, etc.] and II [R2 = CO2Ph, Boc, Cbz; R3 = cyclohexyl, (CH2)3Ph, 2-thienyl, etc.] were synthesized via ligand controlled nickel-catalyzed regiodivergent hydroalkylation of 3-pyrrolines with alkyl/aryl halides. This method demonstrated broad scope and high functional-group tolerance and could be applied in late-stage functionalizations.

Angewandte Chemie, International Edition published new progress about Alkylation catalysts. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gorvin, John H. published the artcileAromatic nitro-group displacement reactions. Part 4. The action of cyanide and halide ions on compounds containing strongly activated nitro groups, Computed Properties of 34133-58-9, the main research area is nitro group displacement reaction; cyanide reaction nitroarom compound; halide reaction nitroarom compound.

Routes for the reaction of cyanide or halide ions in dipolar aprotic solvents with aromatic compounds, e.g., 2-nitroisophthalonitrile, containing strongly activated nitro groups comprise (a) direct displacement of NO2, (b) ring-substitution coupled with hydroxydenitration and (c) (for CN-) fragmentation of NO2 without substitution.

Journal of Chemical Research, Synopses published new progress about Substitution reaction. 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, Computed Properties of 34133-58-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kulkarni, Bheemashankar A. published the artcileA solid-phase equivalent of van Leusen’s TosMIC, and its application in oxazole synthesis, Application of 4-(5-Oxazolyl)benzonitrile, the main research area is solid phase synthesis aryloxazole; oxazole aryl solid phase synthesis.

Polystyrene-SH resin, prepared from Merrifield resin in two steps, was converted to polystyrene-SO2-CH2-NC in three steps. This resin functions as a solid-phase equivalent of p-tolylsulfonylmethyl isocyanide (TosMIC). Thus, reaction with aromatic aldehydes and tetrabutylammonium hydroxide as base yields 5-aryloxazoles.

Tetrahedron Letters published new progress about Solid phase synthesis. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Application of 4-(5-Oxazolyl)benzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bauer, R. published the artcileEnantioselective hydrolysis of racemic 2-phenylpropionitrile and other (R,S)-2-arylpropionitriles by a new bacterial isolate, Agrobacterium tumefaciens strain d3, COA of Formula: C16H13NO, the main research area is Agrobacterium phenylpropionitrile arylpropionitrile enantioselective hydrolysis; nitrile hydratase enantioselectivity Agrobacterium; amidase enantioselectivity Agrobacterium.

Bacteria were enriched from soil samples with succinate as C source and racemic 2-phenylpropionitrile as sole N source. One of the isolates, strain d3, converted (R,S)-2-phenylpropionitrile with high enantioselectivity to (S)-2-phenylpropionic acid. Strain d3 was identified as Agrobacterium tumefaciens. Resting cells hydrolyzed 2-phenylpropionitrile via 2-phenylpropionamide to 2-phenylpropionic acid. Racemic 2-phenylpropionitrile as well as 2-phenylpropionamide were converted to (S)-2-phenylpropionic acid with an enantiomeric excess >96%. The nitrile hydratase and the amidase preferentially both converted the S enantiomer of their resp. substrates. These 2 enzymes were induced in the presence of (R,S)-2-phenylpropionitrile but only in the absence of NH3. In addition to 2-phenylpropionitrile, strain d3 utilized various aliphatic and aromatic nitriles as N sources. Resting cells of strain d3 also converted (R,S)-2-phenylbutyronitrile, ibuprofen nitrile, ketoprofen nitrile, and α-aminophenylacetonitrile with high enantioselectivity. The nitrile- and amide-converting enzyme activities were also found in cell-free extracts

Applied Microbiology and Biotechnology published new progress about Rhizobium radiobacter. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, COA of Formula: C16H13NO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Asskar, Ghada published the artcileGlutaconaldehyde as an Alternative Reagent to the Zincke Salt for the Transformation of Primary Amines into Pyridinium Salts., Product Details of C7H6N2, the main research area is pyridinium salt preparation primary amine glutaconaldehyde zincke.

In the presence of amines, the degradation of glutaconaldehyde in acidic medium can be prevented. By exploiting this behavior, primary amines are transformed into their corresponding pyridinium salts, including those substrates that remain unreactive toward the Zincke salt-the reagent typically used to perform this transformation. The use of glutaconaldehyde also allows controlling the nature of the counterion of the pyridinium with no need for addnl. salt metathesis reaction.

Journal of Organic Chemistry published new progress about Microwave irradiation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts