Author: Jessica.F

Labbe, Gerrit published the artcileSynthesis of fused dihydro-1,2,4-thiadiazolimines from cyano-substituted azides and acyl isothiocyanates, Application In Synthesis of 73217-11-5, the main research area is fused hydrothiadiazolimine; cyano substituted azide cycloaddition acyl isothiocyanate; mechanism cycloaddition acyl isothiocyanate.

Organic azides, bearing a nitrile function at the γ- or δ-position, react with acyl isothiocyanates to give fused dihydro-1,2,4-thiadiazolimines. Representative examples are given. In the case of 2-NCC6H4CH2N3 and BzNCS, the formation of I is accompanied by two side products, II and III. Mechanisms are presented to explain the formation of the products.

Journal of the Chemical Society, Perkin Transactions 10: Organic and Bio-Organic Chemistry published new progress about Azides Role: RCT (Reactant), RACT (Reactant or Reagent). 73217-11-5 belongs to class nitriles-buliding-blocks, name is 2-(2-(Bromomethyl)phenyl)acetonitrile, and the molecular formula is C9H8BrN, Application In Synthesis of 73217-11-5.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sharma, Simmi published the artcileTin(II) triflate Catalysed Synthesis of 3-Methyleneisoindolin-1-ones, SDS of cas: 1885-29-6, the main research area is isoindolinone methylene preparation; acetyl carboxylic acid amine heterocyclization tin triflate catalyst.

A simple and straightforward tin(II) triflate catalyzed facile protocol for the synthesis of 3-methyleneisoindolin-1-ones I (R = 4-BrC6H4, CH2CH(CH3)2, CH2C6H5, etc.; X = C=CH2, CHCH3) and applied to broad range of substrates, which simultaneously offers the functional group tolerance of the reaction and the stability of these scaffolds to the reaction conditions has been described. In addition, in situ reduction of the exocyclic double bond in 3-methyleneisoindolin-1-ones I using PMHS is also reported.

ChemistrySelect published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lang, Xian-Dong published the artcileProtic ionic liquid-catalyzed synthesis of oxazolidinones using cyclic carbonates as both CO2 surrogate and sustainable solvent, Related Products of nitriles-buliding-blocks, the main research area is oxazolidinone preparation; aniline cyclic carbonate carboxylative cyclization.

The synthesis of oxazolidinones I [R1 = H, 3-Me, 4-Cl, etc.; R2 = H, Me] via the carboxylative cyclization of anilines with cyclic carbonate using protic ionic liquid 1,8-diazabicyclo[5.4.0]-7-undecenium imidazolide [HDBU][Im] as the bifunctional catalyst under mild conditions without addition of conventional organic solvents was reported. The distinguished features of this protocol included low catalyst loading, wide functionality tolerance and convenient recycling of the catalyst. A series of functional groups such as -Cl, -Br, -CH3, -OCH3 and -NO2 can be well tolerated under the reaction conditions, provided the corresponding products in moderate to good yields (61-92%). In addition, to shed light on the cooperative interactions of [HDBU][Im]/EC and [HDBU][Im]/aniline, NMR technique and DFT study were also performed, resp.

Catalysis Today published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ghasemzadeh, Maryam Sadat published the artcileAn Eco-Friendly and Efficient Approach for the Synthesis of Tetrazoles via Fe3O4/HT-GLYMO-TA as a New Recoverable Heterogeneous Nanostructured Catalyst, Product Details of C6H4N2, the main research area is substituted tetrazole preparation green chem; tannic acid immobilized functionalized magnetic hydrotalcite reusable green catalyst.

Tannic acid immobilized on functionalized magnetic hydrotalcite (Fe2O4/HT-GLYMO-TA) was synthesized as a durable, environmentally-friendly and magnetic nanostructured catalyst for the synthesis of 5- and 1-substituted-1H-tetrazoles I (R = C6H5, phenanthren-9-yl, 2-thienyl, etc.) and II (R = C6H5, C2H5, 3,4-di-Me-C6H3, etc.). The nanocatalyst was characterized by several methods, Fourier transform IR (FT-IR), X-ray diffraction (XRD) anal., transmission electron microscopy (TEM), field emission SEM (FE-SEM), energy-dispersive X-ray spectroscopy (EDS), EDS-map, thermogravimetric anal. (TGA), vibrating sample magnetometry (VSM) and CHNS anal. The results displayed that the superparamagnetic catalyst with a mean particle size of approx. 23-27 nm has a plate-like shape. The catalytic activity of this new nanostructured catalyst resulted in the preparation of tetrazoles with high yields. Addnl., this novel procedure offers a plethora of benefits including short reaction times, the simplicity of operation, the ease of purification procedure and the reusability of nanocatalyst for at least eight cycles.

ChemistrySelect published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jiang, Ben-Jie published the artcileSynthesis of Quinolines and 2-Functionalized Quinolines by Difluorocarbene Incorporation, Product Details of C7H6N2, the main research area is functionalized quinoline chemoselective preparation; quinoline preparation.

A general method was developed to allow de novo construction of quinolines I [R = Me, cyclopropyl, Ph, etc.] and C2-functionalized quinolines II [R1 = Me, cyclopentyl, Ph; R2 = Ph, Bn, 1-naphthyl, etc.; R3 = H, Me] from ortho-alkenyl anilines in the presence of a difluorocarbene precursor. This method exploited a crucial reactivity of in-situ generation of isocyanides from condensation of primary aniline with difluorocarbene. Subsequent α-addition of isocyanide by neighboring alkenyl group constructs the quinoline ring. Furthermore, when a combination of difluorocarbene precursor and Se are present, selenoisocyanate intermediates were tentatively generated that upon nucleophilic addition by ortho-alkenyl produce 2-SeH quinolines. In the presence of a second nucleophile such as anilines, competing nucleophilic addition of anilines to the selenoisocyanate was preferred, generating selenourea intermediate. Further nucleophilic addition of the ortho-alkenyl to selenourea followed by elimination of H2Se produces 2-aminoquinolines. This allows one-step multi-component modular preparation of various C2-functionalized quinolines from readily available starting compounds This method showed good yields, scope and chemoselectivity. It was operationally convenient and friendly without manipulating unpleasant isocyanides. The difluorocarbene-enabled primary amine to isocyanide conversion may be exploited to develop other interesting reactions.

Advanced Synthesis & Catalysis published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nie, Xufeng published the artcileAcceptorless dehydrogenation of amines to nitriles catalyzed by N-heterocyclic carbene-nitrogen-phosphine chelated bimetallic ruthenium (II) complex, Category: nitriles-buliding-blocks, the main research area is heterocyclic carbene nitrogen phosphine chelate bimetallic ruthenium complex preparation; amine ruthenium complex catalyst dehydrogenation green chem; nitrile preparation.

A clean, atom-economical and environmentally friendly route for acceptorless dehydrogenation of amines to nitriles by combining a new dual N-heterocyclic carbene-nitrogen-phosphine ligand R(CNP)2 (R = o-xylyl) with a ruthenium precursor [RuCl2(η6-C6H6)]2 was developed. In this system, the electronic and steric factors of amines had a negligible influence on the reaction and a broad range of functional groups were well tolerated. All of the investigated amines was converted to nitriles in good yield of up to 99% with excellent selectivity. The unprecedented catalytic performance of this system was attributed to the synergistic effect of two ruthenium centers chelated by R(CNP)2 and a plausible reaction mechanism was proposed according to the active species found via in-situ NMR and HRMS.

Journal of Catalysis published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Cao, Yanwei published the artcileAmine-Responsive Disassembly of AuI-CuI Double Salts for Oxidative Carbonylation, SDS of cas: 100-70-9, the main research area is amine gold copper salt oxidative carbonylation synergistic catalyst; carbamates; double salts; oxidative carbonylation; synergistic catalysis; urea.

A sensitive amine-responsive disassembly of self-assembled AuI-CuI double salts was observed and its use for the synergistic catalysis was enlightened. Study of the disassembly of [Au(NHC)2][CuI2] revealed the contribution of Cu-assisted ligand exchange of N-heterocyclic carbene (NHC) by amine in [Au(NHC)2]+ and the capacity of [CuI2]- on the oxidative step. By integrating the implicative information coded in the responsive behavior and inherent catalytic functions of d10 metal complexes, a catalyst for the oxidative carbonylation of amines was developed. The advantages of this method were clearly reflected on mild reaction conditions and the significantly expanded scope (51 examples); both primary and steric secondary amines can be employed as substrates. The cooperative reactivity from Au and Cu centers, as an indispensable prerequisite for the excellent catalytic performance, was validated in the synthesis of (un)sym. ureas and carbamates.

Angewandte Chemie, International Edition published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Alzieu, Thibaut published the artcileConverting oxazoles into imidazoles: new opportunities for diversity-oriented synthesis, Recommanded Product: 4-(5-Oxazolyl)benzonitrile, the main research area is imidazole preparation; oxazole amine microwave assisted reaction.

We report the optimization of a neglected reaction for the rapid and direct conversion of oxazoles into N-substituted imidazoles. The utility of this microwave-promoted reaction for diversity-oriented synthesis is demonstrated in the preparation of >40 N-substituted imidazoles, including α-imidazolyl esters.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Recommanded Product: 4-(5-Oxazolyl)benzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jiang, Shuai published the artcileCobalt-Catalyzed Isocyanide-Based Three-Component Cascade for the Synthesis of Quinazolines, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is quinazoline preparation; arylisocyanide arylamine azide three component tandem heterocyclization cobalt catalyst.

A Co-catalyzed cyclization reaction of isocyanides 1-NC-4-R-5-R1C6H2CN (R = H, Me, F, OMe, etc.; R1 = H, OMe, Br), azides R2S(O)ON3 (R2 = n-Pr, Ph, cyclohexyl, thiophen-2-yl, etc.), and amines R3NH2 (R3 = n- Bu, Ph, 1-methyl-1H-indol-5-yl, etc.) to access quinazoline derivatives I and II (R4 = H, n-Bu, t-Bu, 4-methylphenyl) was described. This protocol features a high atom economy, mild reaction conditions, excellent yields, and a broad substrate scope. This cascade reaction involved three or four C-N bonds and the formation of one or two rings. The quinazolin-4(H)-imines I and II obtained are proven to be versatile intermediates for further valuable transformations. It was also found that the cobalt catalyst could be isolated from the reaction mixture and reused.

Organic Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mannisto, Jere K. published the artcileOne-Step Synthesis of 3,4-Disubstituted 2-Oxazolidinones by Base-Catalyzed CO2 Fixation and Aza-Michael Addition, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is amine alkenylbromide carbon dioxide tetramethylguanidine carboxylation aza Michael addition; oxazolidinone preparation regioselective; Michael addition; carbon dioxide fixation; cyclization; heterocycles; organocatalysis.

A new, single-step approach to 3,4-disubstituted 2-oxazolidinones by aza-Michael addition using CO2 as a carbonyl source and 1,1,3,3-tetramethylguanidine (TMG) as a catalyst was reported. The modular reaction, which occurred between a γ-brominated Michael acceptor, CO2 and an arylamine, aliphatic amine or phenylhydrazine was performed under mild conditions. The regiospecific reaction displayed good yields (average 75 %) and excellent functional-group compatibility. In addition, late-stage functionalization of drug and drug-like mols. wais demonstrated. The exptl. results suggested a mechanism consisting of several elementary steps: TMG-assisted carboxylation of aniline; generation of an O-alkyl carbamate; and the final ring-forming step through an intramol. aza-Michael addition

Chemistry – A European Journal published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts