Author: Jessica.F

Nagasaki, Yo-hei published the artcileDehydration of Amides to Nitriles over Heterogeneous Silica-Supported Molybdenum Oxide Catalyst, Application of Picolinonitrile, the main research area is silica support molybdenum oxide catalyst preparation surface area; amide silica support molybdenum oxide catalyst dehydration; nitrile preparation.

Silica-supported molybdenum oxide (MoOx/SiO2) with 4.8 wt% Mo (0.5 mmol g-1) was an effective and reusable heterogeneous catalyst for dehydration of 2-furamide to 2-furonitrile (96% yield). The catalyst was applicable to the dehydration of various amides including heteroaromatic, aromatic and alkyl amides, providing the corresponding nitriles in high yields (87-97%). Based on the results of catalyst characterizations (XRD, TEM, UV-vis, Raman) and activity tests, MoOx species are highly dispersed over SiO2, and heptamolybdate anion ([Mo7O24]6-) and isolated dioxo ((O=)2MoO2) were mainly formed on the SiO2 support of the optimal MoOx/SiO2 catalyst. The strong Bronsted acid sites (Mo-OH-Si site) can be formed from the MoOx species and the adjacent silanol group, and the acid-base pair site (Mo(=O)OHSi site) of the strong Bronsted acid site (MoOH-Sisite) and base site (Mo=O) over MoOx/SiO2 catalyst could be themain active site for the dehydration of amides.

ChemCatChem published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Kai published the artcileEfficient dehydration of primary amides to nitriles catalyzed by phosphorus-chalcogen chelated iron hydrides, Computed Properties of 100-70-9, the main research area is nitrile preparation; primary amide dehydration phosphorus chalcogen chelated iron hydride catalyst.

A series of phosphorus-chalcogen chelated hydrido iron (II) complexes, (o-(R’2P)-p-R-C6H4Y)FeH(PMe3)3I (R = H, Me; R’ = iPr, Ph; Y = O, S, Se) were synthesized. The catalytic performances of I for dehydration of amides to nitriles were explored by comparing three factors: (1) different chalcogen coordination atoms Y; (2) R’ group of the phosphine moiety; (3) R substituent group at the Ph ring. It is confirmed that I (R = H; R’ = Ph; Y = S) with S as coordination atom has the best catalytic activity and I (R = H; R’ = Ph; Y = Se) with Se as coordination atom has the poorest catalytic activity among complexes I (R = H; R’ = Ph; Y = O), I (R = H; R’ = Ph; Y = S) and I (R = H; R’ = Ph; Y = Se). Electron-rich complex I (R = Me; R’ = iPr; Y = O) is the best catalyst among the seven complexes and the dehydration reaction was completed by using 2 mol% catalyst loading at 60° with 24 h in the presence of (EtO)3SiH in THF. Catalyst I (R = Me; R’ = iPr; Y = O) has good tolerance to many functional groups. Among the seven iron complexes, new complexes I (R = H, Me; R’ = iPr; Y = O) were obtained via the O-H bond activation of the preligands o-iPr2P(C6H4)OH and o-iPr2P-p-Me-(C6H4)OH by Fe(PMe3)4. Both I (R = H, Me; R’ = iPr; Y = O) were characterized by spectroscopic methods and X-ray diffraction anal. The catalytic mechanism was exptl. studied and also proposed.

Applied Organometallic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ruan, Shixiang published the artcileFacile dehydration of primary amides to nitriles catalyzed by lead salts: The anionic ligand matters, HPLC of Formula: 100-70-9, the main research area is nitrile preparation; primary amide dehydration lead diacetate catalyst.

The synthesis of nitriles RCN [R = n-Pr, 2-MeC6H4, 2-pyridyl, etc.] under mild conditions was achieved via dehydration of primary amides using lead salts as catalyst. The reaction processes were intensified by not only adding surfactant but also continuously removing the only byproduct, water from the system. Both aliphatic and aromatic nitriles could be prepared in this manner with moderate to excellent yields. The reaction mechanisms were obtained with high-level quantum chem. calculations, and the crucial role the anionic ligand played in the transformations were revealed.

Molecular Catalysis published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ren, Shishuai published the artcileDehydration of primary amides to nitriles catalyzed by [CNC]-pincer hydrido cobalt(III) complexes, Application In Synthesis of 100-70-9, the main research area is amide nitrile cobalt hydride catalyst dehydration selective safety; nitrile preparation.

The dehydration reactions from primary amides to nitriles were catalyzed by the [CNC]-pincer hydrido cobalt(III) complexes [(ortho-F4C6-CH=N-C10H6)Co(III)(H)(PMe3)2], [(2,5-F2C6H2-CH=N-C10H6)Co(III)(H)(PMe3)2] (I) and [(2,4,5-F3C6H-CH=N-C10H6)Co(III)(H)(PMe3)2] as catalysts with (EtO)3SiH as an efficient reducing agent. These hydrido cobalt(III) complexes as catalysts are suitable for many substrates and have good functional group tolerance. Among the three cobalt hydrides, complex I is the best catalyst. This is the first hydrido cobalt complex-catalyzed dehydration of primary amides to nitriles.

Catalysis Communications published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Wandi published the artcileSynthesis of nitriles via palladium-catalyzed water shuffling from amides to acetonitrile, HPLC of Formula: 5653-62-3, the main research area is amide dehydration palladium; nitrile preparation; palladium dehydration catalyst.

Palladium-catalyzed synthesis of nitriles from amides has been described. Two similar, but complementary reaction conditions have been identified to convert various amides including α,β,γ,δ-unsaturated amides, cinnamides, aromatic amides and alkyl amides to the corresponding nitriles in good to excellent yield.

Organic & Biomolecular Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, HPLC of Formula: 5653-62-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bhattacharjee, Jayeeta published the artcileN-Heterocyclic Carbene-Phosphinidenide Complexes as Hydroboration Catalysts, Recommanded Product: Picolinonitrile, the main research area is hydroboration catalyst ruthenium osmium NHC carbene phosphinidene half sandwich; crystal structure mol ruthenium osmium NHC phosphinidene half sandwich; ruthenium osmium heterocyclic carbene phosphinidene half sandwich preparation; mechanism kinetics hydroboration ruthenium catalyst NHC phosphinidenide nitrile.

The reactions of the N-heterocyclic carbene-phosphinidene adducts (NHC)PSiMe3 and (NHC)PH with the dinuclear ruthenium and osmium complexes [(η6-p-cymene)MCl2]2 (M = Ru, Os) afforded the half-sandwich complexes [(η6-p-cymene){(NHC)P}MCl] and [(η6-p-cymene){(NHC)PH}MCl2] with two- and three-legged piano-stool geometries, resp. (NHC = IDipp, IMes; IDipp = 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene; IMes = 1,3-bis(2,4,6-trimethylphenyl)imidazolin-2-ylidene). The complexes were initially tested as precatalysts for the hydroboration of benzonitrile, and the most active species, the ruthenium complex [(η6-p-cymene){(IMes)P}RuCl], was further used for the efficient hydroboration of a wide range (ca. 50 substrates) of nitriles, carboxylic esters, and carboxamides in neat pinacolborane (HBpin) under comparatively mild reaction conditions (60-80°C, 3-5 mol % catalyst loading). Preliminary mechanistic and kinetic studies are reported, and stoichiometric reactions with HBpin indicate the initial formation of the monohydride complex [(η6-p-cymene){(IMes)P}RuH] as the putative catalytically active species.

Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhou, Ping-Xin published the artcilePalladium/copper-catalyzed decarbonylative heteroarylation of amides via C-N bond activation, SDS of cas: 87150-13-8, the main research area is aryl oxazole preparation; amide oxazole decarbonylative heteroarylation palladium copper catalyst.

A novel strategy for the synthesis of 2-arylated oxazole derivatives, e.g., 5-(1-naphthalenyl)-2-phenyloxazole via palladium/copper-catalyzed decarbonylative heteroarylation of amides RC(O)NR1R2 (R = C6H5, 2-FC6H4, 1-naphthyl, etc.; R1R2 = -C(O)(CH2)3C(O)-, -C(O)(CH2)2C(O)-) via C-N bond activation by ground-state destabilization has been reported. This transformation shows good functional group tolerance and delivers the versatile 2-arylated oxazole derivatives in moderate to good yields. This transformation provides unique and efficient strategies for converting readily available amides and the precursor carboxylic acids into valuable chems.

Organic Chemistry Frontiers published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, SDS of cas: 87150-13-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Assaf, Jaber published the artcileReconsidering mass spectrometric fragmentation in electron ionization mass spectrometry – new insights from recent instrumentation and isotopic labeling exemplified by ketoprofen and related compounds, Recommanded Product: 2-(3-Benzoylphenyl)propanenitrile, the main research area is electron ionization mass spectrometry isotopic labeling ketoprofen compound.

Rationale : In various fields of chem. analyses, structurally unknown analytes are considered. Proper structure confirmation may be challenged by the low amounts of analytes that are available, e.g. in early stage drug development, in metabolism studies, in toxicol. or in environmental analyses. In these cases, mass spectrometric techniques are often used to build up structure proposals for these unknowns. Fragmentation reactions in mass spectrometry are known to follow definite pathways that may help to assign structural elements by fragment ion recognition. This work illustrates an investigation of fragmentation reactions for gas chromatog./electron ionization mass spectrometric characterization of benzophenone derivatives using the analgesic drug ketoprofen and seven of its related compounds as model compounds Methods : Deuteration and 18O-labeling experiments along with high-resolution accurate mass and tandem mass spectrometry (MS/MS) were used to further elucidate fragmentation pathways and to substantiate rationales for structure assignments. Low-energy ionization was investigated to increase confidence in the identity of the mol. ion. Results : The high-resolution mass analyses yielded unexpected differences that led to reconsideration of the proposals. Site-specific isotopic labeling helped to directly trace back fragment ions to their resp. structural elements. The proposed fragmentation pathways were substantiated by MS/MS experiments Conclusions : The described method may offer a perspective to increase the level of confidence in unknown analyses, where reference material is not (yet) available.

Rapid Communications in Mass Spectrometry published new progress about Gas chromatography-electron ionization mass spectrometry. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Recommanded Product: 2-(3-Benzoylphenyl)propanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lu, Kui published the artcileSynthesis of Substituted Pyrroles via Copper-Catalyzed Cyclization of Ethyl Allenoates with Activated Isocyanides, Product Details of C16H15NO3S, the main research area is pyrrole preparation; ethyl allenoate isocyanide cyclization copper catalyst; allenoates; copper; cyclization; isocyanides; pyrrole synthesis.

A new method for the synthesis of di- and trisubstituted pyrroles I (R1 = H, CH3, t-Bu, Bn, Ph, etc.; R2 = H, CH3, C2H5, Bn, 4-CH3OC6H4, 4-FC6H4; R3 = Ts, 4-ClC6H4SO2, 4-FC6H4SO2, 4-CH3OC6H4SO2, C6H5SO2) via copper-catalyzed cyclization of Et allenoates with activated isocyanides has been developed. In contrast to related annulation reactions previously reported, this new process features a skeletal rearrangement in which the aryl sulfonyl moiety, which functions as the electron-withdrawing group in the α-carbon of the isocyanide, was found to migrate to the γ-carbon of the starting allenoate in the final product for the first time.

Chemistry – An Asian Journal published new progress about Allenes Role: RCT (Reactant), RACT (Reactant or Reagent). 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, Product Details of C16H15NO3S.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Banerjee, Indrani published the artcileAlkali Metal Catalysed Double Hydrophosphorylation of Nitriles and Alkynes, Category: nitriles-buliding-blocks, the main research area is alkali metal silylamide catalyzed hydrophosphorylation nitrile alkyne; crystal mol structure phosphoryl diphenylphosphinic amide.

Catalytic C-P and N-P bond formation via double hydrophosphorylation of nitriles with diphenylphosphine oxide using alkali metal precatalyst [MN(SiMe3)2] (M = Li, Na, K) is reported. The potassium congener was observed to be the most efficient catalyst for converting aryl nitriles to the corresponding N-((diphenyl-phosphoryl)(aryl)methyl)-P,P-diphenylphosphinic amide [ArCHP(O)-Ph2NHP(O)Ph2] at mild temperature (60°) and with neat reactants. Double hydrophosphorylation of alkynes with HP(O)Ph2 is also very effective when [KN(SiMe3)2] is used as a precatalyst at room temperature and gives the corresponding 1,2-diylbis(diphenyl-phosphine) oxide [RCHP(O)Ph2CH2P(O)Ph2] as the product. A wider substrate scope of both reactions is explored.

European Journal of Inorganic Chemistry published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts