Author: Jessica.F

Gajurel, Sushmita published the artcileCuO-NiO bimetallic nanoparticles supported on graphitic carbon nitride with enhanced catalytic performance for the synthesis of 1,2,3-triazoles, bis-1,2,3-triazoles, and tetrazoles in parts per million level, COA of Formula: C6H4N2, the main research area is triazole preparation green chem; arylboronic acid arylacetylene heterocyclization copper nickel dioxide nanocatalyst; benzylhalide arylacetylene heterocyclization copper nickel dioxide nanocatalyst; epoxide phenyl acetylene heterocyclization copper nickel dioxide nanocatalyst; bistriazolyl methane preparation green chem; diazidomethyl methoxybenzene alkyne heterocyclization copper nickel dioxide nanocatalyst; tetrazole preparation green chem; aromatic nitrile heterocyclization copper nickel dioxide nano catalyst.

The unification of CuCl2 ·2H2O and NiCl2·6H2O with the support of graphitic carbon nitride yielded to form an efficient, synergistic, bimetallic nano-catalyst CuO-NiO@g-C3N4. Catalyst with three different molar ratios of Cu and Ni, i.e., Cu75Ni25 (Cu:Ni = 3:1; catalyst-a), Cu50Ni50 (Cu:Ni = 1:1; catalyst-b), and Ni66Cu33 (Ni:Cu = 2:1; catalyst-c), was synthesized, and their catalytic activity was examined The synergistic interaction of one metal with the other on the surface of extremely stable graphitic carbon nitride has enhanced the catalytic performance in the synthesis of triazoles I (R1 = Ph, (4-bromophenyl)methyl, 2-hydroxy-1-phenylethyl, etc.; R2 = H, 4-F, 3-Me, 4-Me, 4-OMe), tetrazoles II (R3 = Ph, pyrazin-2-yl, 4-formylphenyl, etc.), and bis-triazole derivatives III to such a distinguished level (in ppm level), which a monometal fail to possess. The aforementioned statement has been supported by the catalytic activity data provided for both the monometallic and bimetallic catalyst herein. In addition to this, benign reaction conditions, in situ generation of azides, wide reaction scopes, and reusability of the catalyst were also the major advantages leading toward safe and sustainable chem. beyond doubt.

Applied Organometallic Chemistry published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, COA of Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fleckenstein, Christoph A. published the artcile9-Fluorenylphosphines for the Pd-catalyzed Sonogashira, Suzuki, and Buchwald-Hartwig coupling reactions in organic solvents and water, Product Details of C11H12N2O, the main research area is fluorenylphosphine phosphine catalyst Sonogashira Suzuki Buchwald Hartwig coupling reaction.

The lithiation/alkylation of fluorene leads to various 9-alkylfluorenes (alkyl = Me, Et, iPr, Pr, C18H25) in >95% yields, for which lithiation and reaction with R2PCl (R = Cy, iPr, tBu) generates 9-alkyl, 9-PR2-fluorenes which constitute electron-rich and bulky phosphine ligands. The in-situ-formed palladium-phosphine complexes ([Na2PdCl4], phosphonium salt, base, substrates) were tested in the Sonogashira, Suzuki, and Buchwald-Hartwig reactions of aryl chlorides and aryl bromides in organic solvents. The Sonogashira coupling of aryl chlorides at 100-120° leads to >90% yields with 1 mol% of Pd catalyst. The Suzuki coupling of aryl chlorides typically requires 0.05 mol% of Pd catalyst at 100° in dioxane for quant. product formation. To carry out “”green”” cross-coupling reactions in water, 9-ethylfluorenyldicyclohexylphosphine was reacted in sulfuric acid to generate the resp. 2-sulfonated phosphonium salt. The Suzuki coupling of activated aryl chlorides by using this water-soluble catalyst requires only 0.01 mol% of Pd catalyst, while a wide range of aryl chlorides can be quant. converted into the resp. coupling products by using 0.1-0.5 mol% of catalyst in pure water at 100°C. Difficult substrate combinations, such as naphthylboronic acid or 3-pyridylboronic acid and aryl chlorides are coupled at 100° by using 0.1-0.5 mol% of catalyst in pure water to obtain the resp. N-heterocycles in quant. yields. The copper-free aqueous Sonogashira coupling of aryl bromides generates the resp. tolane derivatives in >95% yield.

Chemistry – A European Journal published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Product Details of C11H12N2O.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mo, Xueling published the artcileCopper-Catalyzed Enantioselective Sonogashira Type Coupling of Alkynes with α-Bromoamides, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is copper catalyst enantioselective Sonogashira coupling alkyne alpha bromoamide; Sonogashira reaction; copper catalysis; enantioselectivety; terminal alkynes; α-bromoamide.

An asym. copper-catalyzed Sonogashira type coupling between alkynes and α-bromoamides was developed. This method represents a facile approach to synthetically useful β, γ-alkynyl amides from two readily available starting materials in a highly enantioselective manner. A Bisoxazoline diphenylaniline (BOPA) serves as the effective chiral ligand. Preliminary mechanistic studies support the formation of alkyl radical species.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Biswas, Sovan published the artcileExpedient Synthesis of Bridged Bicyclic Nitrogen Scaffolds via Orthogonal Tandem Catalysis, Product Details of C6H4N2, the main research area is alkylidenenormorphan preparation diastereoselective regioselective; picolinamide gem dibromoalkene alkenylation amidation tandem palladium copper catalyst; alkenylation; bridged bicyclic nitrogen scaffolds; normorphan; remote functionalization; tandem catalysis.

Bridged nitrogen bicyclic skeletons I (R = t-Bu, Ph, cyclohexyl, 1-(benzenesulfonyl)-1H-indol-5-yl, etc.; R1 = H, methoxycarbonyl; R2 = H, Me; X = O, CH2, Et, (tert-butoxy)-formamidyl; Y = O, CH2, Et) have been accessed via unprecedented site- and diastereoselective orthogonal tandem catalysis from readily accessible reactants in a step economic manner. Directed Pd-catalyzed γ-C(sp3)-H olefination of aminocyclohexanes II (X = Y = CH2, Et) with gem-dibromoalkenes RCH=C(Br2), followed by a consecutive intramol. Cu-catalyzed amidation of the 1-bromo-1-alkenylated product III delivers the interesting normorphan skeleton. The tandem protocol can be applied on substituted aminocyclohexanes (X = Y = CH2) and aminoheterocycles II (X = O, (tert-butoxy)-formamidyl; Y = O), easily providing access to the corresponding substituted, aza- and oxa-analogs I. The Cu catalyst of the Ullmann-Goldberg reaction addnl. avoids off-cycle Pd catalyst scavenging by alkenylated reaction product IV. The picolinamides II directing group stabilizes the enamine of the 7-alkylidenenormorphans I, allowing further product V post functionalizations. Without Cu catalyst, regio- and diastereoselective Pd-catalyzed γ-C(sp3)-H olefination is achieved.

Angewandte Chemie, International Edition published new progress about Alkenylation catalysts, stereoselective (regioselective). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bert, Katrien published the artcileChiral imidate-ferrocenylphosphanes: synthesis and application as P,N-ligands in iridium(I)-catalyzed hydrogenation of unfunctionalized and poorly functionalized olefins, Application of 2-Formyl-4,5-dimethoxybenzonitrile, the main research area is chiral imidate ferrocenylphosphine ligand preparation iridium catalyzed hydrogenation olefin; asym hydrogenation unfunctionalized poorly functionalized olefin imidate ferrocenylphosphine iridium.

A small library of chiral imidate-ferrocenylphosphine ligands was efficiently synthesized (8 examples) and evaluated in the iridium(I)-catalyzed hydrogenation of unfunctionalized and poorly functionalized olefins. These catalysts perform very well in a range of examples (yields and ee’s up to 100%).

Organic & Biomolecular Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1013112-48-5 belongs to class nitriles-buliding-blocks, name is 2-Formyl-4,5-dimethoxybenzonitrile, and the molecular formula is C10H9NO3, Application of 2-Formyl-4,5-dimethoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Sheng published the artcileRegioselective umpolung addition of dicyanobenzene to α,β-unsaturated alkenes enabled by electrochemical reduction, Computed Properties of 91-15-6, the main research area is dicyanobenzene unsaturated alkene regioselective electrochem reduction.

An umpolung addition of dicyanobenzene to α,β-unsaturated alkenes has been developed using an electroreductive strategy. This electrochem. protocol is well compatible with a broad range of conventionally challenging substrates, including α,β-unsaturated esters, nitriles and trisubstituted enones. Moreover, good to excellent regioselectivities are observed in the reaction of cinnamates with dicyanobenzene. Synthetic utility of this electrochem. approach is further demonstrated by direct late-stage functionalization of (S)-verbenone and 16-dehydropregnenolone acetate.

Organic Chemistry Frontiers published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Computed Properties of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Karaki, Fumika published the artcileCatalyst-free photooxidation reaction from 1,4-dihydropyridazine to pyridazine under air, Related Products of nitriles-buliding-blocks, the main research area is tetrazine strained alkene inverse electron Dielse Alder reaction photooxidation; pyridazine preparation.

In the inverse electron-demand Diels-Alder (iEDDA) reactions between tetrazines and strained alkenes, a mixture of 1,4-dihydropyridazine isomers are formed first, and they are then oxidized to pyridazines. Although the products of these related oxidation processes converge as pyridazines, the oxidation rate was quite low with some substrates. In this study, 1,4-dihydropyridazines formed in the iEDDA reactions were oxidized to pyridazines by simply irradiating with an UV light under an air atm. Exptl. results implied that singlet oxygen was formed in the course of the reactions to oxidize the 1,4-dihydropyridazine mols.

Tetrahedron published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bera, Srikrishna published the artcileEnantioselective C(sp3)-C(sp3) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis, HPLC of Formula: 100-70-9, the main research area is enantioselective sp3 hybridized carbon cross coupling nickel catalyzed.

Cross-coupling of two alkyl fragments is an efficient method to produce organic mols. rich in sp3-hybridized carbon centers, which are attractive candidate compounds in drug discovery. Enantioselective C(sp3)-C(sp3) coupling is challenging, especially of alkyl electrophiles without an activating group (aryl, vinyl, carbonyl). Here, we report a strategy based on nickel hydride addition to internal olefins followed by nickel-catalyzed alkyl-alkyl coupling. This strategy enables the enantioselective cross-coupling of non-activated alkyl halides with alkenyl boronates to produce chiral alkyl boronates. Employing readily available and stable olefins as pro-chiral nucleophiles, the coupling proceeds under mild conditions and exhibits broad scope and high functional-group tolerance. Applications for the functionalization of natural products and drug mols., as well as the synthesis of chiral building blocks and a key intermediate to (S)-(+)-pregabalin, are demonstrated.

Nature Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Khosravi, Kaveh published the artcileUrea-2,2-dihydroperoxypropane as a Novel and High Oxygen Content Alternative to Dihydroperoxypropane in Several Oxidation Reactions, Synthetic Route of 1885-29-6, the main research area is urea dihydroperoxypropane oxidation; unsaturated ketone alkene epoxidation sulfide oxidation Baeyer Villiger oxidation; aniline phenol bromination oxidative esterification aromatic aldehyde oxidative amidation; aromatic compound thiocyanation pyridine oxidation allylic benzylic alc oxidation.

Urea-2,2-dihydroperoxypropane (UDHPP)- a white crystalline solid oxidant which is formed when urea is recrystallized from dihydroperoxypropane was applied as the terminal oxidant in several oxidative procedures namely epoxidation of α, β-unsaturated ketones and alkenes, oxidation of sulfides to sulfoxides and sulfones, Baeyer-Villiger reaction, bromination and iodation of aniline and phenol derivatives, oxidative esterification, oxidative amidation of aromatic aldehydes, thiocyanation of aromatic compounds, and oxidation of pyridines, oxidation of secondary, allylic and benzylic alcs. All the approaches were carried out under mild conditions and short reaction times and afforded the corresponding products in high yields.

ChemistrySelect published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Khosravi, Kaveh published the artcileUrea-2,2-dihydroperoxypropane as a Novel and High Oxygen Content Alternative to Dihydroperoxypropane in Several Oxidation Reactions, Recommanded Product: Picolinonitrile, the main research area is urea dihydroperoxypropane oxidation; unsaturated ketone alkene epoxidation sulfide oxidation Baeyer Villiger oxidation; aniline phenol bromination oxidative esterification aromatic aldehyde oxidative amidation; aromatic compound thiocyanation pyridine oxidation allylic benzylic alc oxidation.

Urea-2,2-dihydroperoxypropane (UDHPP)- a white crystalline solid oxidant which is formed when urea is recrystallized from dihydroperoxypropane was applied as the terminal oxidant in several oxidative procedures namely epoxidation of α, β-unsaturated ketones and alkenes, oxidation of sulfides to sulfoxides and sulfones, Baeyer-Villiger reaction, bromination and iodation of aniline and phenol derivatives, oxidative esterification, oxidative amidation of aromatic aldehydes, thiocyanation of aromatic compounds, and oxidation of pyridines, oxidation of secondary, allylic and benzylic alcs. All the approaches were carried out under mild conditions and short reaction times and afforded the corresponding products in high yields.

ChemistrySelect published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts