Author: Jessica.F

Guin, Joyram published the artcileCatalytic Asymmetric Protonation of Silyl Ketene Imines, Category: nitriles-buliding-blocks, the main research area is chiral phosphoric acid catalyzed asym protonation silyl ketene imine; nitrile enantioselective synthesis.

An efficient catalytic and highly enantioselective protonation of silyl ketene imines is described. The reaction is catalyzed by the chiral phosphoric acids TRIP or STRIP (I and II, resp.) in the presence of a stoichiometric amount of methanol as the proton source and silyl acceptor. A variety of substituted racemic silyl ketene imines have been transformed into highly enantioenriched nitriles [e.g., (±)-(4-MeOC6H4)MeC:C:NTBS → (S)-(4-MeOC6H4)CHMeCN].

Journal of the American Chemical Society published new progress about Bronsted acids Role: CAT (Catalyst Use), USES (Uses) (chiral). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mohamed, Asmaa H. published the artcileSynthesis of novel quinazolines via nucleophilic cycloaddition of 2-amino-N’-arylbenzimidamides with dimethyl acetylenedicarboxylate and 2-(dicyanomethylene)indan-1,3-dione, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is quinazoline preparation; amino arylbenzimidamide preparation dimethyl acetylenedicarboxylate cycloaddition; dicyanomethylene indan dione amino arylbenzimidamide preparation cycloaddition.

Synthesis of novel tetrahydroquinazoline-2-carboxylate I (R = H, Me; R1 = H, Cl; R2 = H, Me, Cl; R3 = H, Me) and arylaminoquinazoline-2-carboxylate II in good yields has been established via the nucleophilic cycloaddition of 2-amino-N’-arylbenzimidamides III on di-Me acetylenedicarboxylate. Moreover, the reaction of 2-amino-N’-arylbenzimidamides III with 2-(dicyanomethylene)indan-1,3-dione to give 3,4-dihydroquinazolin derivatives IV is studied. A plausible mechanism for the formation of the products is presented.

Monatshefte fuer Chemie published new progress about Benzamidines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Belfield, Andrew J. published the artcileSynthesis of Meta-substituted aniline derivatives by nucleophilic substitution, Recommanded Product: 2-Morpholinobenzonitrile, the main research area is fluorobenzene amine aromatic nucleophilic substitution; aniline derivative preparation; morpholine phenyl preparation.

Substitution by amines of fluorobenzenes containing a meta-substituted electron withdrawing group (EWG), in DMSO at 100°C over 60 h gave meta-substituted aniline derivatives in isolated yields of up to 98%. The scope of the reaction is explored in terms of reaction conditions and substrates. It is postulated that facile meta-substitutions are facilitated through field stabilization of the intermediate anion by EWG substituents.

Tetrahedron published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Recommanded Product: 2-Morpholinobenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sinai, Adam published the artcileAryl-Diadamantyl Phosphine Ligands in Palladium-Catalyzed Cross-Coupling Reactions: Synthesis, Structural Analysis, and Application, Category: nitriles-buliding-blocks, the main research area is aryl diadamantyl phosphine ligand palladium catalyst preparation coupling; Buchwald Hartwig tosyl hydrazone coupling.

Synthesis, temperature-dependent NMR structure study and use of a new, stable and easily accessible aryl-diadamantylphosphine ligand family is reported. The bulky and electron-rich phosphorus center of the ligand enhances the catalytic activity of palladium in cross-coupling reactions of sterically demanding ortho-substituted aryl halides. In the authors’ study, the authors demonstrated the synthetic applicability of the new phosphine ligands in Buchwald-Hartwig and tosyl hydrazone coupling reactions.

European Journal of Organic Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hussain, Muhammad Asif published the artcileAn efficient hydration of nitriles with ruthenium-supported heterogeneous catalyst in water under moderate conditions, HPLC of Formula: 100-70-9, the main research area is nitrile hydration ruthenium supported manganese oxide catalyst moderate condition.

A facile eco-friendly heterogeneous catalytic system has been developed for amide synthesis that further utilized in pharmaceutical and organic chem. The Ru/MnO2 catalyst has shown outstanding and unprecedented activity for a wide range of aliphatic and benzylic nitriles in green solvent water at 60°C. The system has also exhibited a remarkable tolerance for selective hydration of heteroatom (e.g. nitrogen, oxygen and sulfur atoms) containing nitriles. Pharmaceutically important nicotinamides and pyrazinamide has been synthesized by hydration of the heteroat. nitriles with appreciable yields and selectivities. Moreover, the Ru/MnO2 catalyst has employed water as a benign solvent, with more than 30,000 TONs and reusability five times after isolation from the reaction mixture by centrifugation and easy workup that established a path for green environmental and technol. acceptable protocol.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about Amides Role: IMF (Industrial Manufacture), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Naraoka, Asuka published the artcileTransfer Hydration of Dinitriles to Dicarboxamides, COA of Formula: C8H4N2, the main research area is dicarboxamide preparation; dinitrile hydration palladium catalyst acetamide water donor.

A robust method for double transfer hydration of dinitriles to afford diamides was presented. The transfer hydration of 1,n-dinitriles (n = 1-6) proceeds smoothly in the presence of a palladium(II) catalyst with acetamide as a water donor, affording the corresponding diamides in moderate to high yields, without involving significant side reactions such as monohydration or cyclization. The equilibrium was shifted in the forward direction by removing coproduced acetonitrile under reduced pressure.

Synlett published new progress about Diamides Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, COA of Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Moll, Johannnes published the artcileGreen-Light Activation of Push-Pull Ruthenium(II) Complexes, Recommanded Product: Picolinonitrile, the main research area is microwave irradiation preparation ruthenium carboxypyridylmethylaminepyridylpyridine dimethyldipyridinylpyridinediamine complex; crystal mol structure ruthenium carboxypyridylmethylaminepyridylpyridine dimethyldipyridinylpyridinediamine complex; luminescence ruthenium carboxypyridylmethylaminepyridylpyridine dimethyldipyridinylpyridinediamine complex; cyclic voltammetry ruthenium carboxypyridylmethylaminepyridylpyridine dimethyldipyridinylpyridinediamine complex; luminescence; photocatalysis; photochemistry; photophysics; ruthenium.

Synthesis, characterization, electrochem., and photophysics of homo- and heteroleptic ruthenium(II) complexes [Ru(cpmp)2]2+ (22+) and [Ru(cpmp)(ddpd)]2+ (32+) bearing the tridentate ligands 6,2”-carboxypyridyl-2,2′-methylamine-pyridyl-pyridine (cpmp) and N,N’-dimethyl-N,N’-dipyridin-2-ylpyridine-2,6-diamine (ddpd) are reported. The complexes possess one (32+) or two (22+) electron-deficient dipyridyl ketone fragments as electron-accepting sites enabling intraligand charge transfer (ILCT), ligand-to-ligand charge transfer (LL’CT) and low-energy metal-to-ligand charge transfer (MLCT) absorptions. The latter peak around 544 nm (green light). Complex 22+ shows 3MLCT phosphorescence in the red to near-IR spectral region at room temperature in deaerated acetonitrile solution with an emission quantum yield of 1.3% and a 3MLCT lifetime of 477 ns, whereas 32+ is much less luminescent. This different behavior is ascribed to the energy gap law and the shape of the parasitic excited 3MC state potential energy surface. This study highlights the importance of the excited-state energies and geometries for the actual excited-state dynamics. Aromatic and aliphatic amines reductively quench the excited state of 22+ paving the way to photocatalytic applications using low-energy green light as exemplified with the green-light-sensitized thiol-ene click reaction.

Chemistry – A European Journal published new progress about Charge transfer transition (ligand-to-ligand, metal-to-ligand). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Zijuan published the artcilePalladium(II)-Catalyzed Three-Component Tandem Cyclization Reaction for the One-Pot Assembly of 4-Arylquinazolines, SDS of cas: 1885-29-6, the main research area is quinazoline aryl preparation; aminobenzonitrile boronic acid triethyl orthocarboxylate tandem heterocyclization palladium catalyst.

A one-pot method for joining three sep. components leading to an assortment of 4-arylquinazolines I (R1 = H, 6-Cl, 7-Cl, 8-Cl, 6-Me, 6-Br; R2 = H, Me, Ph; R3 = C6H5, 4-ClC6H4, 4-CH3C6H4, etc.) in good to excellent yields is described. The method consists of a palladium(II)-catalyzed cascade reaction involving C(sp)-C(sp2) coupling followed by intramol. C-N bond formation. The reaction was readily scaled up to gram quantity and successfully applied to the synthesis of a translocator protein (TSPO) ligand II.

Synthesis published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ke, Da published the artcileGeneral Construction of Amine via Reduction of N=X (X = C, O, H) Bonds Mediated by Supported Nickel Boride Nanoclusters, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is primary amine preparation; nitrile reduction nickel boride nanocluster catalyst; nitro compound hydrogenation nickel boride nanocluster catalyst; benzaldehyde reduction nickel boride nanocluster catalyst; hydrogenation; nickel boride; primary amine; reductive amination.

Herein, an efficient catalyst for the general construction of amine mediated by nickel boride nanoclusters supported by a TS-1 mol. sieve was reported. Efficient production of amines RCH2NH2 (R = 5-aminopentyl, cyclohexyl, Ph, pyridin-2-yl, etc.), 3-R1-4-R2-C6H3NH2 (R1 = H, F; R2 = H, F, Cl, Me, Br, OH, NH2) was achieved via catalytic hydrogenation of N=X (X = C, O, H) bonds. In addition, the catalyst maintains excellent performance upon recycling. Compared with the previous reports, the high activity, simple preparation and reusability of the Ni-B catalyst in this work make it promising for industrial application in the production of amines.

International Journal of Molecular Sciences published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ke, Da published the artcileGeneral Construction of Amine via Reduction of N=X (X = C, O, H) Bonds Mediated by Supported Nickel Boride Nanoclusters, COA of Formula: C6H4N2, the main research area is primary amine preparation; nitrile reduction nickel boride nanocluster catalyst; nitro compound hydrogenation nickel boride nanocluster catalyst; benzaldehyde reduction nickel boride nanocluster catalyst; hydrogenation; nickel boride; primary amine; reductive amination.

Herein, an efficient catalyst for the general construction of amine mediated by nickel boride nanoclusters supported by a TS-1 mol. sieve was reported. Efficient production of amines RCH2NH2 (R = 5-aminopentyl, cyclohexyl, Ph, pyridin-2-yl, etc.), 3-R1-4-R2-C6H3NH2 (R1 = H, F; R2 = H, F, Cl, Me, Br, OH, NH2) was achieved via catalytic hydrogenation of N=X (X = C, O, H) bonds. In addition, the catalyst maintains excellent performance upon recycling. Compared with the previous reports, the high activity, simple preparation and reusability of the Ni-B catalyst in this work make it promising for industrial application in the production of amines.

International Journal of Molecular Sciences published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, COA of Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts